A major constraint in the treatment of cancer is inadequate oxygenation of the tumor mass, which can reduce chemotherapeutic efficacy. We hypothesize that polymerized human hemoglobin (PolyhHb) can be transfused into the systemic circulation to increase solid tumor oxygenation, and improve chemotherapeutic outcomes. By locking PolyhHb in the relaxed (R) quaternary state, oxygen (O2) offloading ...

Rheology of Microfibrillated Cellulose (MFC) suspensions is useful for designing equipment to transport, mix, or process them. Pressure-driven flow behavior is particularly important for MFC suspensions if they are to be pumped, extruded or coated. Herein, we report use of slot and pipe geometries for determination of MFC suspension rheology and compare the results to boundary-driven flows. MFC...

BACKGROUND This study describes a new method for determining site-specific vascular shear stress using dynamic measures of shear rate and blood viscosity (BV) in the carotid arteries, and examines characteristics of carotid arterial shear stress among patients with lacunar infarction. METHODS Vascular shear stress measurements were conducted in 37 patients (17 lacunar infarction patients and ...

in this paper a laboratory study has been carried out on the effect of changing the type of soil filling cylindrical reinforcing elements from sm to gm on behavior of sandy soil. in this study the primary tests for evaluation of the impact of reinforced sand and gravel columns with diameters of 5 cm and heights of 15 cm subjected to vertical stresses of 50, 100, and 150 kpa were carried out in ...

Abstract The rheological characterization of concentrated suspensions is complicated by the heterogeneous nature their flow. In this contribution, shear viscosity and wall slip velocity are quantified for highly (solid volume fractions 0.55–0.60, D 4,3 ~ 5 µm). was determined using a high-pressure capillary rheometer equipped with 3D-printed die that has grooved surface internal flow channel. t...

Once plaques intrude into the lumen, the shear stress they are exposed to alters with hitherto unknown consequences for plaque composition. We investigated the relationship between shear stress and strain, a marker for plaque composition, in human coronary arteries. We imaged 31 plaques in coronary arteries with angiography and intravascular ultrasound. Computational fluid dynamics was used to ...

Pulsatile motion of blood in a circular tube of varying cross-section has been developed by considering slip flow at the tube wall and the blood to be a non- Newtonian biviscous incompressible fluid. The tube wall is supposed to be permeable and the fluid exchange across the wall is accounted for by prescribing the normal velocity of the fluid at the tube wall. The tangential velocity of the fl...

stress refers to the degree of force used in producing a syllable. all of the words in lexicon regardless of the apparent structure and the number of their syllables have their own stress. given that the regularities governing stress assignment in persian depend on the type of lexical category and that persian speakers have a tendency to assign stress at the end of words, the goal of the presen...

Endothelial cells (ECs) sense shear stress and transduce blood flow information into functional responses that play important roles in vascular homeostasis and pathophysiology. A unique feature of shear-stress-sensing is the involvement of many different types of membrane-bound molecules, including receptors, ion channels and adhesion proteins, but the mechanisms remain unknown. Because cell me...