Pediatric acute respiratory distress syndrome (ARDS) remains an important challenge for the intensive care clinician. ARDS, which can result from either direct lung injury or from a "downstream" inflammatory process, is manifested by profound hypoxemia and respiratory failure. The care of pediatric ARDS is based on a meticulous, multidisciplinary, intensive care team approach. This review discu...

Acute respiratory distress syndrome (ARDS) is a neutrophil-dominant disorder with no effective pharmacological therapies. While the cyclin-dependent kinase inhibitor AT7519 induces neutrophil apoptosis to promote inflammation resolution in preclinical models of lung inflammation, its potential efficacy in ARDS has not been examined. Untreated peripheral blood sepsis-related ARDS neutrophils dem...

Although many various models have been improved in order to form human features of Acute Respiratory Distress Syndrome (ARDS) in animals, there is no single animal model that satisfactorily exhibits all of the histopathological components of human ARDS. Therefore, when choosing an ARDS animal model, it is important to consider the ARDS key property to be tested as a study hypothesis and choose ...

CONTEXT Acute lung injury (ALI) and ARDS are currently defined by the American-European Consensus Conference (AECC) definition criteria, which contain a radiographic criterion. The accuracy or reliability of this consensus radiographic definition has not been evaluated, and no radiographic definition of ALI-ARDS has been evaluated by a large international group of experts. OBJECTIVE To study ...

Since acute respiratory distress syndrome (ARDS) was first described in 1967 there has been large number of studies addressing its pathogenesis and therapies. Despite this intense research activity, there are very few effective therapies for ARDS other than the use of lung protection strategies. This lack of therapeutic modalities is not only related to the complex pathogenesis of this syndrome...

BACKGROUND Obesity is associated with the development of acute respiratory distress syndrome (ARDS) in at-risk patients. Low plasma levels of adiponectin, a circulating hormone-like molecule, have been implicated as a possible mechanism for this association. The objective of this study was to determine the association of plasma adiponectin level at ICU admission with ARDS and 30-day mortality i...

BACKGROUND Acute respiratory distress syndrome (ARDS) is a critical condition characterized by bilateral pulmonary infiltrates and severe hypoxemia. This study aimed to evaluate the diagnostic and prognostic values of Club cell protein 16 (CC16) in critical care patients with ARDS. METHODS In this retrospective observational study, 83 patients with ARDS and 129 non-ARDS patients on ICU admiss...

Introduction:  One ofdiagnostic criteria for Acute Lung Injury and Acute Respiratory Distress Syndrome is  pao2/fio2 (PF) ratio 300 for ALI or 200 for ARDS. This criteria requires invasive arterial sampling. Measurement of Spo2/Fio2 (SF) ratio by pulseoximetry may be a reliable non invasive alternative to the PF ratio.   Methods and Materials: In a cross sectional study we enrolled 105 sample o...

A cute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are important public health issues, and both incidence and mortality increase with age [1]. Given that only a moderate percentage of individuals with the same level of exposure develop ALI/ ARDS, it is logical to investigate whether inherent interindivid-ual variation will, in part, determine the risk...