نتایج جستجو برای: aripiprazolebinary systemscyclodextrinin vitro dissolution phase solubility

تعداد نتایج: 1023304  

Journal: :Biological & pharmaceutical bulletin 2014
Wenji Li Ka-yun Ng Paul Wan Sia Heng

The aim of this study was to develop optimized sucrose ester (SE) stabilized oleanolic acid (OA) nanosuspensions (NS) for enhanced delivery via wet ball milling by design of experiments (DOE). In this study, SEOA NS batches were prepared by wet ball milling method. Mean particle sizes and polydispersity indices were determined using a nanosizer. The percent encapsulation efficiency, saturation ...

Journal: :Crystals 2022

This study aims to improve the dissolution rate of ketoprofen by preparing multicomponent crystals with tromethamine. The (equimolar ratio) and tromethamine were prepared solvent co-evaporation method. solid-state properties resulting powder characterized X-ray diffraction, DSC thermal analysis, FT–IR spectroscopy, solubility, in vitro rate. crystal structure was determined single-crystal diffr...

Journal: :iranian journal of pharmaceutical research 0
jin bin liao school of chinese materia medica, guangzhou university of chinese medicine, guangzhou, china. yong zhuo liang school of chinese materia medica, guangzhou university of chinese medicine, guangzhou, china. yun long chen school of chinese materia medica, guangzhou university of chinese medicine, guangzhou, china. jian hui xie school of chinese materia medica, guangzhou university of chinese medicine, guangzhou, china. wei hai liu dongguan mathematical engineering academy of chinese medicine, guangzhou university of chinese medicine, dongguan, china jian nan chen institute of higher education, guangzhou university of chinese medicine, guangzhou, china.

the present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (pa) that can be used for the preparation of immediate release pellets formulation. two commercially available grades poloxamer 188 (p 188) and poloxamer 407 (p 407) were selected, and solid dispersions (sds) conta...

2014
Ibrahim Elsayed Aly Ahmed Abdelbary Ahmed Hassen Elshafeey

CONTEXT Diacerein (DCN) has low aqueous solubility (3.197 mg/L) and, consequently, low oral bioavailability (35%-56%). To increase both the solubility and dissolution rate of DCN while maintaining its crystalline nature, high pressure homogenization was used but with only a few homogenization cycles preceded by a simple bottom-up technique. METHODS The nanosuspensions of DCN were prepared usi...

Journal: :Pakistan journal of pharmaceutical sciences 2014
Ghulam Murtaza Shujaat Ali Khan Muhammad Najam-ul-Haq Izhar Hussain

Drugs with good solubility exhibit good oral absorption, and subsequently good bioavailability. Thus, most exigent phase of drug development practice particularly for oral dosage forms is the enhancement of drug solubility. This review describes various traditional and novel methodologies proposed for the solubility enhancement of furosemide. For furosemide, solubility and permeability are cruc...

2013
Mathew Leigh Bastian Kloefer Michael Schaich

The equilibrium solubility values and dissolution profiles in each of the media (FaSSIF or FaSSIF-V2) produced using methylene chloride and the corresponding SIF Powder are equivalent for the drugs tested representing acid, basic, and neutral compounds. Therefore, it is practical to switch from the more labor-intensive solvent-evaporation method to the use of standardized instant powders for pr...

Natvarlal Patel Vipul Patel,

      Glipizide has been found to form inclusion complexes with β-cyclodextrin (β-CD) in solution and in solid state. The present study was undertaken to determine a suitable method for scaling up glipizide-β-CD inclusion complex formation and to evaluate the effect of some parameters on the efficiency of complexation. The solid inclusion complexes of glipizide and β-CD were prepared at a molar...

2012
Harjeet Singh Betty Philip Kamla Pathak

The solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. Fused dispersions (FDs) of simvastatin (SIM) using PEO-PPO block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. The accumulative solub...

Journal: :iranian journal of pharmaceutical sciences 0
lakshmi pk g.pulla reddy college of pharmacy, affliated to osmania university, hyderabad-28 swetha reddy g.pulla reddy college of pahrmacy,medhipatnam, hyderabad kishore c g.pulla reddy college of pahrmacy, mehdipatnam,hyderabad satish reddy g.pulla reddy college of pharmacy, mehdipatnam, hyderabad

lamotrigine is used in the treatment of cns disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. lamotrigine belongs to biopharmaceutical classification systems, bcs class ii (low solubility & high permeability). in addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...

2011

Solubility of drug plays a prime role in controlling its dissolution from dosage form. Aqueous solubility of drug is a major factor that determines its dissolution rate. Minimum aqueous solubility of 1% is required to avoid potential solubility limited absorption problems. Studies of 45 compound of different chemical classes and a wide range of solubilities revealed that initial dissolution rat...

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