Atrial fibrillation (AF) is the most common form of arrhythmia in the world. As the population ages, it is estimated that the prevalence of AF will increase by 2.5 fold in the next 50 years.1 At the same time, diabetes has become a pandemic disease in the western world as well as in developing countries. Independent risk factors for chronic AF include hypertension, heart failure, valvular heart...

BACKGROUND Altered conduction is associated with increased atrial fibrillation (AF) vulnerability in canine models of chronic mitral regurgitation (MR) and heart failure (HF). Rotigaptide (ZP123) augments gap junction conductance, improving cell-to-cell coupling. We studied the effects of rotigaptide on atrial conduction and AF vulnerability in the canine MR and HF models. METHODS AND RESULTS...

Catheter ablation is an important treatment modality for management of Atrial Fibrillation (AF). AF a responsible factor in the pathophysiology Heart Failure with Preserved Ejection Fraction (HFpEF). However, relationship between and Right Ventricular (RV) dysfunction has not been completely distinguished.

Why discuss atrial fibrillation in hypertension? Atrial fibrillation (AF) is the most frequently occurring sustained cardiac arrhythmia and is related to many cardiac diseases. Its prevalence doubles with each decade after 50 years and approaches 10% in those more than 80 years of age [1]. In men and women, respectively, hypertensive patients have a 1.4and 1.5-fold risk of developing AF [1], an...

BACKGROUND The long-term outcome of atrial fibrillation (AF) ablation demonstrates attrition. This outcome may be due to failure to attenuate the progressive substrate promoted by cardiovascular risk factors. OBJECTIVES The goal of this study was to evaluate the impact of risk factor and weight management on AF ablation outcomes. METHODS Of 281 consecutive patients undergoing AF ablation, 1...

Atrial fibrillation (AF) is the most frequent arrhythmia. Due to population aging, AF is a growing epidemic and its importance will continue to increase in the next decades. Although the prevalence of AF is high in advanced age, the number of subjects with predisposing factors for AF is even higher. Most of these factors increase the risk of atrial fibrosis, an important component of atrial arr...

BACKGROUND Antiflammin-1 (AF-1), a derivative of uteroglobin (UG), is a synthetic nonapeptide with diverse biological functions. In the present study, we investigated whether AF-1 has a protective effect against bleomycin-induced pulmonary fibrosis. METHODS C57BL/6 mice were injected with bleomycin intratracheally to create an animal model of bleomycin-induced pulmonary fibrosis. On Day 7 and...

BACKGROUND Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are essential for the cardiac extracellular matrix (ECM) remodeling. We investigated differences in serum levels of these markers between patients with atrial fibrillation (AF) and sinus rhythm (SR). METHODS Serum levels of MMP-2, MMP-3, MMP-9 and TIMP-1 were measured in 86 patients: 27 on SR without any AF histor...

BACKGROUND Advanced age is the most important risk factor for atrial fibrillation (AF); however, the mechanism remains unknown. Telomeres, regions of DNA that shorten with cell division, are considered reliable markers of biological aging. We sought to examine the association between leukocyte telomere length (LTL) and incident AF in a large population-based cohort using direct LTL measurements...

In this study, the Axial Flux Synchronous Reluctance Motor (AF-SynRM) with multiple barriers in its rotor is designed and it aimed to compare performance Induction (AF-IM) same stator structure dimensions. For an equal comparison, motor dimensions are chosen same, only changed. preliminary study of designs, machine calculated analytically modeled 3D Finite Element Method (FEM). To optimize sali...