INTRODUCTION In this study, we focused on the medically important problem of long bone wound healing by regeneration. We employed a small animal in vivo load-bearing model to study the effect of a biocompatible artificial polymer scaffold on regeneration of critical size defects in adult Xenopus laevis frog hind limbs. The long-term goal is to repair large segmental critical size (non-regenerat...

Although the incidence of fulminant hepatic failure appears to have decreased worldwide, the management of this dreaded condition remains unsatisfactory (1). Despite ingenious methods of treatment, the mortality in patients with grade IV coma is still between 80 and 90% in most major series (15, 20). Furthermore the mortality is nearly 100% in patients ov~r the age of 45 who develop grade IV co...

This study is focused on in vitro permeation of the original Czech compound, a skin/mucosa tissue regeneration promoter, known under the international nonproprietary name "alaptide," in micronized and nanonized forms. Alaptide showed a great potential for local applications for treatment and/or regeneration of the injured skin. The above mentioned technological modifications influence the perme...

One of the major challenges of microsurgery is nerve regeneration across lesions. In this respect it is very important to assess whether a peripheral nerve is reconstructed and how much of its initial function has been restored. Several methods are available for this purpose: function tests, histological techniques, neurophysiologic tests. The present paper addresses magnetoneurography (MNG), a...

The search for advanced biomimetic materials that are capable of offering a scaffold for biological tissues during regeneration or of electrically connecting artificial devices with cellular structures to restore damaged brain functions is at the forefront of interdisciplinary research in materials science. Bioactive nanoparticles for drug delivery, substrates for nerve regeneration and active ...

Artificial bone materials that exhibit high biocompatibility have been developed and are being widely used for bone tissue regeneration. However, there are no biomaterials that are minimally invasive and safe. In a previous study, we succeeded in developing honeycomb β-tricalcium phosphate (β-TCP) which has through-and-through holes and is able to mimic the bone microenvironment for bone tissue...

T issue engineering (TE) is one of the biomedical technologies developed to assist the regeneration of body tissues to treat large size defects that are not possible to self-repair. TE may also help to substitute the biological functions of damaged organs by making use of cells. Although there is no doubt that cells are important for this purpose, an artificially created site to induce repair o...

Polymeric biomaterials are widely used in a wide range of biomedical applications due to their unique properties, such as biocompatibility, multi-tunability and easy fabrication. Specifically, polymeric hydrogel materials are extensively utilized as therapeutic implants and therapeutic vehicles for tissue regeneration and drug delivery systems. Recently, hydrogels have been developed as artific...

Biological multicellular structures can not only self-generate from a single cell but also self-regenerate after damage. In this paper we investigate self-regeneration in a model of artificial development, Epigenetic Tracking. 3-dimensional cellular structures grown using our model reach a size and a level of complexity unmatched by other models in the field, thanks to several features of Epige...

root canal therapy has enabled us to save numerous teeth over the years. the most desired outcome of endodontic treatment would be when diseased or nonvital pulp is replaced with healthy pulp tissue that would revitalize the teeth through regenerative endodontics. ‘a search was conducted using the pubmed and medline databases for articles with the criteria ‘platelet rich plasma’, ‘platelet rich...