General biochemistry detection on paper-based microanalytical devices (PADs) uses pipette titration. However, such an approach is extremely time-consuming for large-scale detection processes. Furthermore, while automated methods are available for increasing the efficiency of large-scale PAD production, the related equipment is very expensive. Accordingly, this study proposes a low-cost method f...

OBJECTIVES The increase of serum aspartate aminotransferase (AST) is generally found in hepatic, cardiac, muscular disease and hemolytic disorders of the red blood cell (RBC). The elevation of its activity is suspected in pathological conditions of these organs. However, instances without any of those conditions rarely exist. METHODS The experimental samples were obtained from a normal person...

Elevated enzyme activities in plasma may sometimes be due to the presence of macroenzymes.1,2 Macroenzymes are high molecular mass complexes of plasma enzymes with immunoglobulins (IgG, IgA or IgM) or other plasma components with reduced plasma clearance and prolonged half life, resulting in elevated serum activities due to the “trapping” of the enzymes in serum.3 These results may thus be erro...

Submit Manuscript | http://medcraveonline.com MOJ Toxicol (2016), 2(1): 00026 Abbreviations: RPM: Revolutions Per Minute; AST: Serum Aspartate Aminotransferase; ALT: Serum Glutamate Pyruvate Transaminase; Scr: Serum Creatinine; BUN: Blood Urea Nitrogen; C: Control; V: Venom; VC : Vitamin; VVC: Venom+Vitamin C ; TBS :Tris Buffered Saline; SOD: Superoxide Dismutase; Cat: Catalase; GSH-Px: Glutath...

Submit Manuscript | http://medcraveonline.com Abbreviations: AD: Alzheimer’s Disease; CDR: Clinical Dementia Rating; MNA: Mini Nutritional Assessment; HDL: High Density Lipoprotein; LDL: Low Density Lipoprotein Levels; Aβ: Accumulation of Beta-Amyloid; NINCDS-ADRDA: National Institute of Neurologic and Communicative Disorders and Stroke and the Alzheimer Disease and Related Disorders Associatio...

Abbreviations: HMG-CoA: 3-Hydroxy-3-Methylglutaryl Coenzyme A; JUPITER: The Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin; LDL-C: Low Density Lipoprotein Cholesterol; TG: Triglycerides; HOMAIR: Homeostasis Model Assessment for Insulin Resistance; GIR: Glucose Infusion Rate; FPG: Fasting Plasma Glucose; CK: Creatinine Phosphokinase; AST: Aspart...

Hepatomegaly is a common finding in primary myelofibrosis (PMF), mostly due to extramedullary hematopoiesis, as demonstrated by liver biopsies in previous studies, and high serum alkaline phosphatase (ALP) is usually the most frequent associated biochemical abnormality. In the current study, we examined the clinical, prognostic and molecular correlates of increased ALP and aspartate aminotransf...

BACKGROUND Non-alcoholic steatohepatitis (NASH) is a clinicopathological entity that is being recognized more frequently in recent years. This study aimed to evaluate the effects of Metformin, with and without a probiotic supplement on liver aminotransferases in patients with NASH. METHODS Sixty four patients 18-75 years with NASH confirmed by biopsy and histological assessment were enrolled ...

BACKGROUND Preterm premature rupture of membranes (PPROM) occurs in 3% of pregnancies and 30-40% of preterm labors are related to this problem. Early diagnosis of PPROM is very important due to its impact on pregnancy outcomes. OBJECTIVE To determine the diagnostic value of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in vaginal fluid for the diagnosis of preterm...

Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are a very aggressive type of cancer, for which prognostic factors are lacking. We analysed clinical and histomorphological prognostic markers of overall survival (OS), completed with a record of biological and haematological data of patients diagnosed between December 2002 and December 2015. The median OS was 16 months (95% CI 13.9-18....