Quantifying the magnitude and dynamics of protein oxidation during cell signaling is technically challenging. Computational modeling provides tractable, quantitative methods to test hypotheses of redox mechanisms that may be simultaneously operative during signal transduction. The interleukin-4 (IL-4) pathway, which has previously been reported to induce reactive oxygen species and oxidation of...

Vitrimers are a new class of sustainable cross-linked materials with an associative bond exchange mechanism. Bond in vitrimers functions addition/elimination pathway, where dissociation and reassociation appear to occur simultaneously, as opposed traditional dynamic covalent bonds that act discrete distinct, separated steps reassociation. Because these characteristics, network disconnection nev...

Redox signaling and oxidative stress are associated with tissue fibrosis and aging. Aging is recognized as a major risk factor for fibrotic diseases involving multiple organ systems, including that of the lung. A number of oxidant generating enzymes are upregulated while antioxidant defenses are deficient with aging and cellular senescence, leading to redox imbalance and oxidative stress. Howev...

Arrays of chemical oxidants are produced in healthy cells, where they function as important signaling molecules that are crucial in homeostatic regulation and cellular adaptation. The molecular basis of “redox signaling” is a series of oxido-reductive chemical reactions in which oxidants or reductants posttranslationally alter the structure of proteins. These modifications equate to signal sens...

The time course of availability of associative and item information was examined by using a response signal procedure. Associative information discriminates between a studied pair of words and a pair with words from two different studied pairs. Item information is sufficient to discriminate between a studied pair and a pair not studied. In two experiments, discriminations that require associati...

Background: Exposure of the skin against occupational hazards is growing every day. Many scientists are trying to identify aspects about the mechanisms of damages done to the skin by them. The skin is the second metabolism organ of the body where redox-dependent metabolic pathways overcome. By considering the UV index, Iranians are at high risk of UVB damage by generation of reactive oxygen spe...

Oxidative and nitrosative stress are primary contributors to the loss of myocardial tissue in insults ranging from ischemia/reperfusion injury from coronary artery disease and heart transplantation to sepsis-induced myocardial dysfunction and drug-induced myocardial damage. This cell damage caused by oxidative and nitrosative stress leads to mitochondrial protein, DNA, and lipid modifications, ...

We have synthesized a set of double-labeled fluorescent probes and evaluated the performance of these fluorescent probes in sequencing by ligation (SBL). The results indicated that the ligation efficiency and specificity of double-labeled fluorescent probes was as higher as that of singe-labeled fluorescent probes. Moreover, double-labeled f luorescent p robes y ielded a r emarkable i ncrease i...

A long-standing hypothesis termed "Hebbian plasticity" suggests that memories are formed through strengthening of synaptic connections between neurons with correlated activity. In contrast, other theories propose that coactivation of Hebbian and neuromodulatory processes produce the synaptic strengthening that underlies memory formation. Using optogenetics we directly tested whether Hebbian pla...

Various mechanisms for authenticating users of computer-based information systems have been proposed. These include traditional, user-selected passwords, system-generated passwords, passphrases, cognitive passwords and associative passwords. While the mechanisms employed in primary passwords are determined by the operating systems' manufacturers, system designers can select any password mechani...