Supraphysiological ROS levels can lead to apoptosis, lipid peroxidation, and DNA protein damage. This pilot study aimed investigate the sperm oxidative damage in subfertile men, describe relationship between antioxidant system ROS. Sixty-four semen samples were categorised according evaluated routine parameters (WHO, WHO laboratory manual for examination processing of human semen, 2010). Result...

a:4:{s:9:"Objective";s:402:"Uric acid (UA) is crucial for sperm metabolism; it protects seminal plasma against oxidative damage. Zinc, too, plays a central role in sperm metabolism. The current study was designed to investigate the role of zinc supplementation on the qualitative and quantitative properties of seminal fluid, in parallel with the UA level and urate pathway enzymes in the semen of...

Background: Zinc in human semen seems to play an important role in the physiology of spermatozoa. Zinc deficiency leads to gonadal dysfunction, decreases testicular weight, and causes shrinkage of seminiferous tubules. The adult human body contains 1-3 g of zinc, about 0.1% of which is replenished daily. Excessively high amounts of zinc has been reported in human seminal plasma by many authors,...

We measured the blood plasma testosterone (T) levels and superoxide dismutase (SOD) and catalase activities in the seminal plasma of the ejaculates of 5 normal (2-5 years old) and 5 asthenozoospermic (AZ-) (3-5 years old) Beagles. Sperm ejaculated by AZ-dogs was incubated for 3 hr in Eagle's MEM only (controls) or Eagle's MEM containing 100 units/ml of SOD or catalase. Sperm motility was examin...

The first complete mitochondrial DNA (mtDNA) sequences (approximately 16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played b...

Background: A great number of substances have been found in sperm plasma but so far it has not been possible to provide evidence of clinical significance for all of them. Fructose occupies the most important place in biochemical investigations. Fructose acts as a donor of energy to the spermatozoa. Fructose is secreted from the seminal vesicles and the accessory sex glands. It is the major carb...