Current screening methods for diabetic kidney disease (DKD), characterized by albumin excretion in urine, are expensive or only identify patients late stages. Hence, there is need a cost-effective, quick, and portable tool which identifies at DKD onset. Here we report that ultracentrifugation coupled with infrared spectroscopy machine learning can quantify low level microalbuminuria urine sampl...

The influence of the support (Al2O3, CeO2, TiO2) in oxidation benzyl alcohol (BA) to benzaldehyde on Ir-based catalysts was investigated by ATR-IR spectroscopy tandem with modulation excitation (ATR-IR-MES) at working conditions catalysts. ATR-IR-MES unveiled dissociative adsorption BA and formation adsorbed transient alkoxy species (C6H5CH2O) be key for high catalytic performance. These were d...

Fourier Transform Infrared spectroscopy is used as a diagnostic tool in biological and physical sciences by characterizing the samples based on infrared light-matter interaction. In the case of biological samples, Activation of Jurkat T-cells in culture following treatment with anti-CD3 (Cluster of Differentiation 3) antibody is detectable by interrogating the treated T-cells using the Attenuat...

Evaluation of Pre-Fixed Biological Tissues Preparation Methods for ATR-FTIR Biospectroscopy Fourier transform infrared (FTIR) spectroscopy in ATR (attenuated total reflection) mode is a powerful tool for studying biomedical samples, which can provide important structural information on the molecular composition. Currently, formalin fixation and paraffin preservation (FFPP) is the preferred sourc...

Nanoparticles appear to induce toxic effects through a variety of mechanisms including generation of reactive oxygen species (ROS), physical contact with the cell membrane and indirect catalysis due to remnants from manufacture. The development and subsequent increasing usage of nanomaterials has highlighted a growing need to characterize and assess the toxicity of nanoparticles, particularly t...

BACKGROUND The seminal plasma is an excellent source for noninvasive detection of spermatogenesis. The seminal plasma of normospermic and azoospermic men has been analyzed for detection of spermatogenesis. METHODS Optical spectroscopy (Attenuated Total Reflectance-Infrared spectroscopy (ATR-IR) and Fourier Transform infrared spectroscopy (FT-IR) has been used to analyze the seminal plasma and...

Nanotechnology has introduced many manufactured carbon-based nanoparticles (CNPs) into our environment, generating a debate into their risks and benefits. Numerous nanotoxicology investigations have been carried, and nanoparticle-induced toxic effects have been reported. However, there remain gaps in our knowledge, primarily regarding mechanism. Herein, we assessed the global alterations induce...

The present work is aimed at investigating the mechanical and in vitro biological properties of polyphenylene ether ether sulfone (PPEES)/nanohydroxyapatite (nHA) composite fibers. Electrospinning was used to prepare nanofiber composite mats of PPEES/nHA with different weight percentages of the inorganic filler, nHA. The fabricated composites were characterized using Fourier transform infrared ...

Modifications of phenylalanine amino acid after its exposure to near-infrared (NIR) radiation have been investigated using ATRFTIR (Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy). The process of amino acid aggregation after its exposure to NIR has been observed. A possible mechanism of amino acid dimer formation has been proposed with the help of theoretical calculations ...