Conduction time from the region of the sinus node to the region of the atrioventricular (A-V) node was studied during open heart surgery in 13 patients with an endocardial cushion type atrial septal defect, eight patients with a secundum type atrial septal defect, one patient with a sinus venosus type atrial septal defect, and eight patients with an intact atrial septum. Internodal conduction t...

Background—Mutations of the transcription factor Nkx2-5 cause pleiotropic heart defects with incomplete penetrance. This variability suggests that additional factors can affect or prevent the mutant phenotype. We assess here the role of genetic modifiers and their interactions. Methods and Results—Heterozygous Nkx2-5 knockout mice in the inbred strain background C57Bl/6 frequently have atrial a...

Holt-Oram syndrome is an autosomal dominant disorder, characterised by skeletal abnormalities of the upper limb associated with congenital heart defect, mainly atrial and ventricular septal defects. Skeletal defects exclusively affect the upper limbs in the preaxial radial ray distribution and are bilateral and asymmetrical. They range from clinodactyly, absent or digitalised thumb, hypoplastic...

introduction: along with advances occurring in cardiopulmonary bypass (cpb) including improved anesthesia intubation and early surgical interventions, it has become possible to correct life-threatening congenital heart anatomic abnormalities in patients. our study aimed to collect information from one of the most important centers of pediatric cardiac surgery in iran since there is limited info...

BACKGROUND Mutations of the transcription factor Nkx2-5 cause pleiotropic heart defects with incomplete penetrance. This variability suggests that additional factors can affect or prevent the mutant phenotype. We assess here the role of genetic modifiers and their interactions. METHODS AND RESULTS Heterozygous Nkx2-5 knockout mice in the inbred strain background C57Bl/6 frequently have atrial...

Conduction time from the region of the sinus node to the region of the atrioventricular (A-V) node was studied during open heart surgery in 13 patients with an endocardial cushion type atrial septal defect, eight patients with a secundum type atrial septal defect, one patient with a sinus venosus type atrial septal defect, and eight patients with an intact atrial septum. Internodal conduction t...

INTRODUCTION Heart injuries can be classified as penetrating and non-penetrating (blunt). Penetrating wounds are usually caused by stabbing with a piercing object, weapon or projectiles--missiles. The right atrium is damaged in most cases, because of its anatomical position--making the most of the anterior side of the heart. Morbidity caused by stabbing injuries to the heart is 20%-30%, while p...

PURPOSE For the successful completion of transcatheter closure of atrial septal defects with the Amplatzer septal occluder, shape of the defects should be considered prior to selecting the device. The purpose of this study is to evaluate the results of a transcatheter closure of oval shaped atrial septal defect. MATERIALS AND METHODS From November 2009 until November 2011, cardiac computed to...