The atypical antipsychotics have advanced the treatment of schizophrenia and have proved to be effective agents in treating other disorders with or without psychotic features. We review the literature concerning an increasingly reported and interesting adverse effect, atypical antipsychotic-induced obsessive-compulsive symptoms (OCS). The first known report of quetiapine exacerbating OCS in a 4...

Background and Objectives: Several studies have shown an improved performance on neuropsychological tests among patients treated with atypical antipsychotics compared to traditional ones. Here we present a meta-analysis of various randomised control trials with the aim of exploring whether patients treated with atypical agents obtain better results than those treated with traditional ones. Meth...

BACKGROUND The introduction of atypical antipsychotics in the management of adult bipolar disorder has been increasingly adopted in clinical setting. While new studies continue to emerge, NICE has recently updated the guidelines on the assessment and management of bipolar disorder. AIM To review the efficacy and tolerability profiles of atypical antipsychotics used to treat adult bipolar diso...

OBJECTIVES To investigate the association between use of typical and atypical antipsychotic drugs and incidence of stroke in patients with and without dementia. DESIGN Self controlled case series. SETTING UK based electronic primary care records in the general practice research database (GPRD). PARTICIPANTS All patients registered in the database with a recorded incident stroke and at lea...

Atypical antipsychotics have replaced conventional antipsychotics in the treatment of schizophrenia because they have less of a propensity to cause undesirable neurologic adverse events including extrapyramidal symptoms, tardive dyskinesia, and neuroleptic malignant syndrome (NMS). However, atypical antipsychotics have been known to result in various metabolic complications such as impaired glu...

Background: Patients with unipolar depression present a unique challenge for physicians who are considering therapeutic drug treatment. Physicians have historically treated patients who present symptoms of unipolar depression with SSRIs or other medications that are commonly prescribed to patients with non-unipolar depression. Many of these medications are ineffective for patients suffering fro...

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OBJECTIVES To investigate the effects of atypical antipsychotics on prepulse inhibition, startle response and habituation in acutely psychotic patients with schizophrenia, and investigate whether prepulse inhibition deficit improvements are a result of the direct impact of atypical antipsychotics or improvements in antipsychotic-related symptoms. METHODS Prepulse inhibition, habituation and ...

BACKGROUND There is currently mixed opinion regarding the value of using atypical antipsychotics to treat anorexia nervosa (AN). AIMS To evaluate the literature on the use of atypical antipsychotics in AN. METHOD A review of all studies and clinical guidelines published before September 2009 involving use of an atypical antipsychotic in patients with AN. Analysis is by narrative synthesis. ...

BACKGROUND In two recent randomised clinical trials, a meta-analysis and in an effectiveness study analysing routine data from the U.S. Veterans Administration the superiority of the newer atypical drugs over typical antipsychotic drugs, concerning both their efficacy and their side-effect profile, has been questioned. AIMS OF THE STUDY To analyse the effectiveness and cost of atypical versus...