BACKGROUND Annual Pap smear screening has been favored over less frequent screening in the United States to minimize the risk of cervical cancer. We evaluated whether simultaneous screening with a Pap test and human papillomavirus (HPV) testing is useful for assessing the risk for cervical intraepithelial neoplasia (CIN) 3 or cervical cancer. METHODS We enrolled 23 702 subjects in a study of ...

Cases of atypical glandular cells (AGC) diagnosed on liquid-based preparations were culled from a 3-year period. When available, residual cellular material was analyzed for human papillomavirus (HPV) by polymerase chain reaction and correlated with cytologic and histologic (biopsy) outcome. Of 178,994 cytologic cases, 187 (0.1045%) contained AGC compared with 8,740 (4.8828%) atypical squamous c...

Cervical cancer is one of the most common cancers affecting women worldwide, constituting 6% of all female malignancies. It is the most common female genital tract malignancy in Calabar, Nigeria. Although the incidence and mortality from cervical cancer have decreased substantially in the past several decades among women in the United States, cervical cancer remains the third gynecologic malign...

Specimen Adequacy TBS 1991 reported the adequacy of cervical cytology preparations in three categories: “satisfactory,”“unsatisfactory,”and “satisfactory but limited by,” or SBLB. SBLB included factors such as the lack of transformation zone components and the presence of partially obscuring factors (i.e., blood or inflammation). This category was confusing to some clinicians and prompted unnec...

OBJECTIVES To assess whether automated screening in the cytologic examination of Papanicolaou smear slides results in smaller margins of error than manual screening. METHODS We compared cytotechnologists' performance and reproducibility of manual and automated screening of 10,165 consecutive cervical cytology slides examined at Barretos Cancer Hospital using the FocalPoint system. RESULTS I...

OBJECTIVES Sex workers are at increased risk for sexually transmitted infections (STI), human papillomavirus (HPV) and hence cervical cancer. In Belgium screening for cervical cancer starts at the age of 25, and is at 3 yearly intervals. The aim of this study is to assess risks for abnormal cervical smears and HPV in sex workers and decide whether the current screening policy is sufficient for ...

A subcutaneous mass in the left supraclavicular fossa of a 55-year-old woman proved on histological examination to be composed of islands of squamous cells embedded in bands of spindle cells and associated with mature adipose tissue. Electron microscopy showed that the spindle cells were fibroblastic in nature and not squamous cells showing spindle differentiation. There was also a minor lympha...

Background: With the implementation of primary high-risk human papillomavirus (hrHPV) screening in Netherlands, an increase was observed number unnecessary referrals (?Cervical Intraepithelial Neoplasia (CIN) 1) to colposcopy. We aimed investigate which alternative triage strategies safely reduce HPV-based cervical cancer programmes. Methods: Microsimulation model MISCAN used simulate unvaccina...

Introduction: Cervical cancer is amongst the leading causes of death in females. According to World Cancer Statistics, global incidence cervical 6.5% and mortality related it 7.5%. The most effective way screen thus treat early stages achieved by screening patients with Papanicolaou (Pap) smear. Aim: To assess spectrum lesions Pap smears, classify them as per Bethesda System reporting Cytology ...

INTRODUCTION This study aims to compare the antioxidant abilities of cervical squamous carcinoma cells and cervical adenocarcinoma cells and to study the related mechanisms. MATERIAL AND METHODS Cervical squamous carcinoma and adenocarcinoma cells were treated with H2O2. Cell proliferation was determined with the MTT assay. The reactive oxygen species (ROS) level was detected by the 2',7'-dic...