1 INOVA Diagnostics, Inc., 9900 Old Grove Road, San Diego, CA 92131-1638, USA 2Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA 3 Laboratorio di Ricerche in Immunoreumatologia, Università di Milano, Istituto Auxologico Italiano, 20095 Cusano Milanino, Italy 4 Faculty of Medicine, ...

Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Patients affected by vitiligo usually show a poorer quality of life and are more likely to suff...

Autoimmune polyglandular syndromes (APS) bring together immune mediated disease of endocrine and nonendocrine organs that manifest in an individual lifelong. On the basis of the genetic errors involved and the association of autoimmune disorders, autoimmune polyglandular syndromes are classified in two different groups: APS type I and type II. Sometimes a rare association of autoimmune disorder...

Department of Medicine D, Sheba Medical Center, Tel Hashomer, Israel Division of Rheumatology, Sheba Medical Center, Tel Hashomer, Israel Autoimmune Disease Center, Sheba Medical Center, Tel Hashomer, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel *Author for correspondence: [email protected] SUMMARY: Antibiotics have been applied for the treatment of autoimmune ...

Autoimmune diseases (ADs) have close relationship with the onset of malignant lymphoma. They closely tie to lymphoma. Immune disorders might play an important role in transformation from ADs to lymphoma. DLBCL occurred after autoimmune hematological diseases and autoimmune lymphoproliferative syndrome (ALPS) was rare. The interval between ADs and DLBCL was long and the pathogenesis might be rel...

CONTEXT There are contradictory results on the effect of hypothyroidism on the changes in hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). This paper reviews the studies on laboratory and population-based findings regarding hemostatic changes and risk of VTE in hypothyroidism and autoimmune thyroid disorders...

A multicenter study of 308 children with Autism Spectrum Disorder (ASD) was conducted through the Collaborative Programs of Excellence in Autism (CPEA), sponsored by the National Institute of Child Health and Human Development, to compare the family history of autoimmune disorders in children with ASD with and without a history of regression. A history of regression was determined from the resu...

Autoimmune thrombotic thrombocytopenic purpura (TTP) can be associated with other autoimmune disorders, but their prevalence following autoimmune TTP remains unknown. To assess the prevalence of autoimmune disorders associated with TTP and to determine risk factors for and the time course of the development of an autoimmune disorder after a TTP episode, we performed a cross sectional study. Two...

Complement receptor 1 (CR1) has gained much attention in recent years. The reason is manifold. Growing understanding on this protein has facilitated insight into the pathophysiology of autoimmune disorders. CR1, a polymorphic protein, is important as a complement regulatory protein, as well as a vehicle for immune complex clearance. Functional and clinical significance of CR1 polymorphism is a ...

Venous thromboembolism (VTE) is major health problem and is sometimes complicated by lethal pulmonary embolism (PE). Disturbances of the coagulation and anticoagulation systems are important risk factors for VTE. Comparative studies suggest that coagulation and innate immunity have a shared evolutionary origin. It is therefore unsurprising that the immune and coagulation systems are linked, wit...