A UTOIMMUNE HEMOLYTIC ANEMIA may complicate a wide variety of diseases, among which are infectious diseases, “collagen” diseases, benign tumors, malignant tumors, lymphomas and Hodgkin’s disease.1’2 The lymphoproliferative disorders, especially chronic lymphatic leukemia, have often been associated with abnormal immunologic mechanisms. The myeloproliferative disorders are rarely associated with...

Background Autoimmune lymphoproliferative syndrome (ALPS) a disease which is based on primary violations lymphocyte apoptosis caused by various molecular defects: mutation in the proapoptotic receptor Fas (la ALPS type) or its ligand FasL (Ib type), a mutation in the gene caspase10 (type II), or an unidentified defect in the signaling pathway of Fas-receptor (III type). The typical clinical pic...

OBJECTIVE A human lymphoproliferative syndrome characterized by a defect of the Fas-mediated apoptosis pathway in the absence of a fas gene mutation (Autoimmune Lymphoproliferative Disease) has recently been described and characterized by autoimmune phenomena. The aim of this study was to investigate the presence of antinuclear and antiphospholipid antibodies and to define their specificity in ...

Karunatilake and Pidcock [1] recently described an interesting patient with autoimmune manifestations, cytopenias and lymphoproliferation. However, the authors did not comment on several important aspects. Did the patient have any lymphadenopathy, and was there a family history of a similar condition? Was the presence of double negative T cells in the peripheral blood looked for, was an aptotos...

Autoimmunity and immune dysregulation may lead to cytopenia and represent key features of many primary immunodeficiencies (PIDs). Especially when cytopenia is the initial symptom of a PID, the order and depth of diagnostic steps have to be performed in accordance with both an immunologic and a hematologic approach and will help exclude disorders such as systemic lupus erythematosus, common vari...

Autoimmune diseases (ADs) have close relationship with the onset of malignant lymphoma. They closely tie to lymphoma. Immune disorders might play an important role in transformation from ADs to lymphoma. DLBCL occurred after autoimmune hematological diseases and autoimmune lymphoproliferative syndrome (ALPS) was rare. The interval between ADs and DLBCL was long and the pathogenesis might be rel...