Critical limb ischemia (CLI) is a vascular disease affecting lower limbs, which is going to become a demanding challenge because of the aging of the population. Despite advances in endovascular therapies, CLI is associated with high morbidity and mortality. Patients without direct revascularization options have the worst outcomes. To date, 25%-40% of CLI patients are not candidates for surgical...

There will be an estimated 180,000 new cases of breast cancer this year with 46,000 deaths. Adjuvant chemotherapy is now firmly established as a valuable modality in breast cancer, improving both disease-free and overall survival in appropriate patients. Unfortunately, chemotherapy has yielded little improvement in the survival of patients with metastatic breast cancer.

ABSTRACT Objectives: to assess/correlate health-related quality of life with the social dimension hematopoietic, autologous and allogeneic stem cell transplant patients in three years post-transplant. Methods: longitudinal, observational study 55 patients, a reference hospital Latin America, from September 2013 February 2019, using Quality Life Questionnaire-Core Functional Assessment Cancer Th...

The quality of long-term hematopoietic engraftment after bone marrow transplantation (BMT) has not been well characterized. Clinical autologous BMT involves removal of <5% of the total content of the recipient marrow followed by ablation of the remaining marrow and reinfusion. To study long-term consequences of transplanting limited numbers of BM stem cells further, we evaluated the hematopoiet...

Over the last 20 years allogeneic bone marrow transplantation from an HLA-identical sibling donor has become the treatment of choice for a number of human haematological malignancies, severe aplastic anaemia, some congenital diseases of the immune and haemopoietic systems, and some inborn errors of metabolism. Recently, the successful introduction of HLA-matched unrelated donor transplants, con...

background:  infections  in  neutropenic  patients  are  considered  as  major  causes  of  mortality and the emergence of drug resistance. gram positive bacterial infections are crucially important to be covered if indicated. vancomycin is active against most gram positive bacteria including methicillin resistant staphylococcus aureus (mrsa). in this study, we evaluated the appropriate utiliza...

introduction : infections in neutropenic patients are considered as major causes of mortality and emergence of drug resistant gram positive bacterial infections are crucially important to be covered if indicated. vancomycin is active against most gram positive bacteria including methicillin resistant staphylococcus aureus (mrsa). in this study, we evaluated the appropriate utilization of this a...