A 3-year-old Quarter Horse filly presented with an acute history of right hindlimb lameness. Examination the hind found moderate effusion in medial femorotibial joint and a consistent grade 4/5 Ultrasonographic evaluation revealed disruption synovial membrane recess capsule. Arthroscopy identified tear capsule at attachment to collateral ligament. Treatment autologous conditioned serum, rest fi...

The low titer and incidence of autologous antibody to melanoma has hampered its evaluation. Through acid dissociation and ultrafiltration of serum, we have been able to augment the autologous immune response in 9 of 10 patients studied. This result suggests that autologous antibody is present in most patients with melanoma, but is obscured by circulating antigen and the formation of immune comp...

In a case of chronic thrombocytopenic purpura, significant lymphocyte transformation could be induced with autologous platelets as a stimulant. The reaction was not due to serum factors since it occurred when culture medium was supplemented either with autologous or pooled human serum. Controls excluded nonspecific lymphocyte transformation. Modulation of normal platelet antigens by viral or ch...

Influenza A virus-treated human platelets were lyzed in autologous serum. Lysis required the presence of antibody and occurred predominantly through activation of the classical complement pathway. Binding of the virus followed by its elution at 37 degrees C resulted in a dose-dependent desialation of the cells with a maximal release of 45% of total platelet sialic acid. In contrast, platelets t...

Human serum-derived and plasma-derived therapies have become increasingly popular in the treatment of ocular surface disorders, with mounting clinical and scientific evidence suggesting good safety and efficacy profiles. These therapies may be considered for various ocular surface conditions, such as dry eye syndrome and persistent epithelial defect, when conservative management does not suffic...

Hematopoietic stem cell (HSC) mobilization is still not well understood. Accumulating evidence suggests that protease activation is an important step: proteases release cytokines or chemokines from the extracellular matrix, thereby modulating biological responses.1,2 The urokinase-type plasminogen activator receptor (uPAR) is the receptor for urokinasetype plasminogen activator (uPA). The ligan...

Background: Autologous serum (ASST) and plasma (APST) skin testing confirm autoreactivity in chronic spontaneous urticaria (CSU). Whole blood autohemotherapy has been used. Plasma even whole may be used instead of with relatively quicker preparation cheaper method especially using the latter centers limited resources. Purpose: The purpose study is to determine if similar intradermal reactions c...

Objective The aim of this study was to obtain autologous dermal-epidermal skin substitutes from oral mucosa from diabetic subjects as a first step towards a possible clinical application for cases of diabetic foot. Material and Methods Oral mucosa was obtained from diabetic and healthy subjects (n=20 per group). Epidermal cells were isolated and cultured using autologous fibrin to develop der...