BACKGROUND Immunoglobulin (Ig) A deficiency is a primary immunodeficiency in which autoimmunity is frequently observed. Thirty to fifty percent of patients with spontaneous chronic urticaria have autoantibodies that are able to cross-link FcεRI on mast cells and basophils. METHODS We investigated whether spontaneous chronic urticaria in patients with IgA deficiency meets the criteria for auto...

A 43-year-old man with generalized lichen planus demonstrated serum antibodies against autologous lesional skin. Indirect immunofluorescence using serum and papular lesional skin revealed a lichen planus specific antigen found only in the granular layer. The specific tissue antigen was not detected in normal skin from this patient, in normal skin from patients with skin disorders other than lic...

Methods Patient blind, parallel group, randomised, controlled study of two study arm. 54 patients were given AST (GroupA) and control group of 57 patients given injection normal saline (placebo) (GroupB). AST/Placebo was given every week for 9 weeks and then followed-up for another 3 weeks. Levocetrizine was advised to be taken SOS in both groups. AU was diagnosed by autologous serum skin test....

nowadays, cell -based and tissue engineered products have opened new horizons in treatment of incurable nervous system disorders. the number of studies on the role of schwann cells (sc) in treating nervous disorders is higher than other cell types. different protocols have been suggested for isolation and expansion of sc which most of them have used multiple growth factors, mitogens and fetal b...