R espiratory infections by the opportunistic pathogen Pseudomonas aeruginosa in immunocompromised patients or in patients with cystic fibrosis (CF) are the result of unique conditions that allow this Gram-negative bacterium to colonize the lung. This interaction between the pathogen and host leads to responses in both cells that ultimately lead to severe lung degeneration in individuals with CF...

Detailed neuroanatomical information is an essential prerequisite for functional analysis of specific neurones in the central nervous system. In this investigation we have combined the dissection of single axons with cobalt-backfilling to reveal the structural organisation of a class of interganglionic giant interneurones in the central nervous system of the cockroach, Periplaneta americana (L)...

A unique approach, combining defined and reproducible in vitro models with DNA microarrays, has been developed to study environmental modulation of mycobacterial gene expression. The gene expression profiles of samples of Mycobacterium tuberculosis, from independent chemostat cultures grown under defined and reproducible conditions, were found to be highly correlated. This approach is now being...