Cardiovascular disorders are the main complication in autosomal dominant polycystic kidney disease (ADPKD). contributing to both morbidity and mortality. This review considers clinical studies unveiling cardiovascular features patients with ADPKD. Additionally, it focuses on basic science addressing dysfunction of polycystin proteins located system as a factor abnormalities. In particular, effe...

A utosomal dominant polycystic kidney disease (ADPKD) is a genetic condition characterised by the formation of multiple fluid-filled renal cysts and kidney enlargement. Potential complications of ADPKD include adult-onset end-stage kidney disease, early-onset hypertension and nephrolithiasis. ADPKD is also associated with systemic conditions including intracranial cerebral aneurysm and polycyst...

Mutations in TRPP2 (polycystin-2) cause autosomal dominant polycystic kidney disease (ADPKD), a common genetic disorder characterized by progressive development of fluid-filled cysts in the kidney and other organs. TRPP2 is a Ca(2+)-permeable nonselective cation channel that displays an amazing functional versatility at the cellular level. It has been implicated in the regulation of diverse phy...