background: sentinel  lymph  node  biopsy  has  shown  to  be  a  good  alternative procedure  for  axillary  lymph  node  dissection  and  to lead  to  lower  frequency  of morbidity, though this technique has its own side effects. it needs especial equipment and may not be available in some medical centers, especially in developing countries. this study aimed to identify a subgroup of patient...

Systemic delivery of an anti-cancer agent often leads to only a small fraction of the administered dose accumulating in target sites. Delivering anti-cancer agents through the lymphatic network can achieve more efficient drug delivery for the treatment of lymph node metastasis. We show for the first time that polymeric gold nanorods (PAuNRs) can be delivered efficiently from an accessory axilla...

CXCR4 is a 7-transmembrane G-protein chemokine receptor that allows for migration of hematopoietic cells from the bone marrow to the peripheral lymph nodes. Research has shown CXCR4 to be implicated in the invasion and metastasis of several cancers, including carcinoma of the breast. CXCL12 is the ligand for CXCR4 and is highly expressed in areas common for breast cancer metastasis, including t...

The main goals of the clinical use of tumor markers are to evaluate the adequacy of the treatment, monitor recurrence and follow up response to the treatment applied. For this purpose a baseline level for the commonly used tumor marker must be known at the time of initial diagnosis, before any therapy, in order to compare with the tumor marker levels which will be obtained after the treatment a...

Ectopic breast tissue has the ability to undergo all the pathological changes of the normal breast, including breast cancer. Gastrointestinal metastasis of breast cancer is rarely observed and it is very difficult to differentiate gastric metastases from primary gastric cancer. We present a case of 52-year-old female, who suffered from abdominal pain. Physical examination showed a palpable mass...

Here we describe a breast cancer case from a 36-year-old female 4 months after delivery. During lactation, she had a painful large lump in the left breast, accompanied by erythema and edema of the 1/3 skin of the breast. Surgical biopsy confirmed that it was a case of invasive breast cancer without special type, grade 3, triple-negative/ basal-like subtype (ER-, PR-, HER2-, CK5&6+, EGFR+) and n...

A randomized trial was conducted at the Institut Gustave-Roussy (IGR) between 1972 and 1980 comparing tumorectomy and breast irradiation with modified radical mastectomy. One hundred and seventy-nine patients with an infiltrating breast carcinoma up to 20 mm in diameter at macroscopic examination were included: 88 had conservative management, and 91 a mastectomy. All patients had a low-axillary...

A case of synchronous carcinoma of the accessory mammary gland and primary breast lymphoma with subsequent rectal carcinoma has not been reported previously. We present a very rare case of primary non-Hodgkin lymphoma of the left breast diagnosed simultaneously with invasive lobular carcinoma of the left axillary accessory mammary gland and rectal adenocarcinoma. An 82-year-old Japanese woman p...

Sentinel lymph node biopsy (SLNB) has become standard to stage the axilla in cases of clinically and Ultrasound negative avoiding unnecessary axillary Lymph dissection which is associated with higher morbidity patients 1. The Primary objective preoperatively detect metastasis USG confirmed perform Biopsy, 2. To negate need for treatment breast cancer sentinel A total number 80 core needle prove...