نتایج جستجو برای: axin2
تعداد نتایج: 430 فیلتر نتایج به سال:
Axin2 loss, we are over-expressing a drug-stabilised b-catenin construct in wild-type skull osteoblast cultures, and in skull explant (calvarial) cultures. Using a drug-dependent b-catenin will allow us to investigate the threshold levels of Wnt signalling required for ossification and the stages at which the b-catenin signal is critical for osteoblast differentiation. Our findings from these i...
Vascular medial calcification is often observed in patients with arteriosclerosis. It is also associated with systolic hypertension, wide pulse pressure, and fluctuation of blood pressure, which results in cardiovascular events. Eicosapentaenoic acid (EPA) has been shown to suppress vascular calcification in previous animal experiments. We investigated the inhibitory effects of EPA on Wnt signa...
It has previously been observed that a loss of β-catenin expression occurs with melanoma progression and that nuclear β-catenin levels are inversely proportional to cellular proliferation, suggesting that activation of the Wnt/β-catenin pathway may provide benefit for melanoma patients. In order to further probe this concept we tested LY2090314, a potent and selective small-molecule inhibitor w...
High grade neuroepithelial tumor of the central nervous system with BCOR alteration (CNS HGNET-BCOR) is a recently described new tumor entity with a dismal prognosis. The objective of this study was to identify and validate pathways deregulated in CNS HGNET-BCOR as basis for targeted therapy approaches.We characterized the BCOR alteration in a pediatric patient with CNS HGNET-BCOR diagnosis by ...
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