Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During...

background and objectives : hepatitis c virus genotyping appears to be vital for predicting the response to antiviral therapy. the present study aimed to analyze the hcv genotypes in relation to persistence or clearance of the virus in residents of hamadan province, west-iran. material and methods : a total of 1159 recorded questionnaires of hcv infected people were evaluated in this prospectiv...

Background: Previous studies have shown increases in endothelin (ET) concentration of plasma and renal tissues in acute renal failure (ARF).  ET has a potent vasoconstrictor effect, through binding with its ETA receptors, and may play some roles in renal hemodynamic dysfunction in ARF.Objective: To examine the beneficial effect of a selective ETA-receptor antagonist on renal dysfunction and tis...

This document defines the syntax and semantics for the Clearance attribute and the Authority Clearance Constraints extension in X.509 certificates. The Clearance attribute is used to indicate the clearance held by the subject. The Clearance attribute may appear in the subject directory attributes extension of a public key certificate or in the attributes field of an attribute certificate. The A...