I processes invariably employ interesting biochemistry,” declares Marc Kirschner (1). From this statement, one may readily conclude that antizyme (AZ) deserves our attention. AZ is the central element in a feedback loop that controls cellular polyamines. AZ is interesting for a number of reasons. First, AZ production requires the exercise of a remarkable mechanism, translational frameshifting. ...

Solid-state electron transport (ETp) via a monolayer of immobilized azurin (Az) was examined by conducting probe atomic force microscopy (CP-AFM), as a function of both temperature (248-373K) and applied tip force (6-15 nN). At low forces, ETp via holo-Az (with Cu(2+)) is temperature-independent, but thermally activated via the Cu-depleted form of Az, apo-Az. While this observation agrees with ...

The 2694 ORFs originally annotated as potential genes in the genome of Aeropyrum pernix can be categorized into three clusters (A, B, C), according to their nucleotide composition at three codon positions. Coding potential was found to be responsible for the phenomenon of three clusters in a 9-dimensional space derived from the nucleotide composition of ORFs: ORFs assigned to cluster A are codi...

The heat shock protein HSP70 plays antiapoptotic and oncogenic roles, and thus its inhibition has been recognized as a potential avenue for anticancer therapy. Here we describe the small molecule, apoptozole (Az), which inhibits the ATPase activity of HSP70 by binding to its ATPase domain and, as a result, induces an array of apoptotic phenotypes in cancer cells. Affinity chromatography provide...

In a previous publication (l), we reported that when 1 mg of a pure concentrate of anhydrovitamin A2 (4’-ethoxy anhydrovitamin Ai, E:%m at 370 rnp = 2248 in light petroleum ether), and 0.5 mg of a-tocopherol are fed daily to vitamin A-deficient rats, growth is resumed, xerophthalmic lesions are cured, and a new compound named rehydrovitamin A* showing absorption maxima at 330,348, and 365 rnp c...

We associate with every ~ c 2 ~ the upset U(~) = {U c gt : U D E for some E E ~} and the downset ~ ) ( 8 ) {D c ~ : D C E for some E C $}. W h e n ~d is an antichain in the poset (2 ~, D), then the identi ty becomes 1 w a ( x ) = 1. (1) ~ ~ + ~ Ixl(,;~,------5 xe~ (Ixr) xeu(~)\~ The LYM inequality is obtained by omission of the second summand, which by definition of W~ can also be wri t ten in ...

The purpose of this study was to extend knowledge on how children understand their affiliation with an animal that can evoke both fear and care: bats. We interviewed 120 children, evenly divided between four age groups (6–7, 9–10, 12–13, and 15–16 years) after each child had visited an exhibit at Brookfield Zoo that displays Rodrigues fruit bats. Results showed that in the same children a fear ...

A Smarandache system (Σ;R) is such a mathematical system with at leastone Smarandachely denied rule r in R such that it behaves in at least two different wayswithin the same set Σ, i.e., validated and invalided, or only invalided but in multiple dis-tinct ways. A map is a 2-cell decomposition of surface, which can be seen as a connectedgraphs in development from partition to per...

Cikkem témája az ész ómagyar kori konceptualizációjának részleges rekonstruálása 23 kódex adatai alapján. Ez a téma egy részcél, és hosszabb távú kutatás fontos eleme; amely pedig elme végigkövetése írásbeliség kezdeteitől napjainkig. A fogalom alakulásának felvázolásához elengedhetetlen mint rokon értelmű szó vizsgálata, így első szakaszban adatait elemeztem (lásd Szabó 2021), s ezután e két ö...

Absiract-AZ fractiond-N frequency synthesis achieves low pham noise performance while daring the Phase-Locked h p (PLL) design constraints and reduces the desired channel spacing This paper reviews the recent advanced techniques on the implementation of fractiond-N frequency synthesizers and discusses their advuntages nnd disadvantages. It nlso addresses the design options and the asPodated tra...