نتایج جستجو برای: b and t lymphocyte attenuator
تعداد نتایج: 17065848 فیلتر نتایج به سال:
The herpes virus entry mediator (HVEM) delivers a negative signal to T cells mainly through the B and lymphocyte attenuator (BTLA) molecule. Thus, HVEM/BTLA may represent novel immune checkpoint during an anti-tumor response. However, formal demonstration that HVEM can target for cancer immunotherapy is still lacking. Here, we first showed BTLA mRNA expression levels were associated with worse ...
thirty seven randomly selected patients suffering from multiple s c l e r os i s (ms) (17 males and 20 females)and 30 healthy control subjects were studied for the lymphocyte subpopulations and ce l l -medi a t e d immunity.we obs e r ved a decrease of the total t-cells and an increase of a ctive t-lymphocytes and b ce l l s , in ms p at i ent s as compared t o normal controls. the inability of...
Behcet's disease (BD) is a chronic, systemic and recurrent inflammatory disease associated with hyperactive Th17 and Th1 immune responses. Recent studies have shown that B and T lymphocyte attenuator (BTLA) negatively regulates the immune response. In this study, we investigated whether BTLA activation could be exploited to inhibit the development of abnormal immune responses in BD patients. BT...
The etiology of most human autoimmune diseases remains largely unknown. However, investigators have identified several negative regulatory mechanisms acting at the level of innate and/or adaptive immunity. Mutations resulting in a deficiency of some key regulatory molecules are associated with systemic or organ-specific inflammatory disorders, which often have a prominent autoimmune component. ...
The cosignaling network mediated by the herpesvirus entry mediator (HVEM; TNFRSF14) functions as a dual directional system that involves proinflammatory ligand, lymphotoxin that exhibits inducible expression and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes (LIGHT; TNFSF14), and the inhibitory Ig family member B and T lymphocyte attenuator (BTLA). To dissect t...
The host immune system plays a significant role in tumor control, although most cancers escape immune surveillance through a variety of mechanisms. The aim of the present study was to evaluate the clinicopathological significance of a novel co-inhibitory receptor, B and T lymphocyte attenuator (BTLA), the anergy cell marker Casitas-B-lineage lymphoma protein-b (Cbl-b), and clinical implications...
BACKGROUND Nonspecific T-cell hyperactivation is the main driving force for human immunodeficiency virus (HIV)-1 disease progression, but the reasons why the excess immune response is not properly shut off are poorly defined. METHODS Eighty-five HIV-1-infected individuals were enrolled to characterize B and T lymphocyte attenuator (BTLA) expression and function. Infection and blockade assays ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید