Erythropoietin (EPO) was first known as a factor for red blood cell proliferation and differentiation. Recent studies show the effects of EPO on immune system. In this study the antihuman leukocyte antibody (anti-HLA) titer were determined in five groups of rats, which had been sensitized with human lymphocyte. Also, the effects of stimulation's frequency and dose of recombinant human erythropo...

The capacity of retinole acid to modulate human T-lymphocyte and B-lymphocyte activation by mitogens was examined. Tlymphocyte proliferation stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) or phytohemagglutinin was enhanced by 5 nw to 5 U.Mretinoic acid in a dose-dependent manner with a 65 ± 35% (SD) increase (n = 6, P < 0.01) in TPA-stimulated proliferation induced by 5 U.Mretinoic a...

The macrophage has been implicated in the elaboration of a spectrum of molecules which alter or modulate the functions of hemopoietic and lymphoid cells. These include colony-stimulating factor (CSF),' required for the renewal and clonal proliferation of granulocyte-macrophage stem cells in semisolid culture (1), lymphocyte-activating factor which potentiates the mitogenic response of T lymphoc...