Extensive research on the formation of methionine has implicated vitamin B12 as a cofactor in the final reaction of the biosynthetic sequence. Since plants and fungi do not produce or require B12, an alternate reaction must also exist. It is thus not surprising that Escherichia coli has been found to possess two mechanisms for the methylation of homocysteine to methionine (9). These reactions a...

Background and objectives: Breast carcinoma is one of the most common malignant diseases among women worldwide. In Iraq there are noticeable elevation in incidence rates and prevalence of advanced stages of breast cancer. Cobalamin (vitamin B12) is essential micronutrient involved in one carbon metabolism and DNA methylation, which affects cancer. All of these may be change in breast cancer. Th...

Objective: Oral isotretinoin is the most effective agent in treatment of acne vulgaris. The risk pigmentation due to systemic may be associated with decrease serum levels Vit B12. study aims contribute literature by defining association between increase caused oral [O-ISO] use and low vitamin B12 level [vit-B12]. Methods: In our we evaluated 144 patients, who have facial acnes at medium degree ...

OBJECTIVE To assess the prevalence and clinical features of B12 deficiency in hypothyroid patients and to evaluate clinical response in symptoms to B12 replacement therapy. METHODS One hundred and sixteen hypothyroid patients from our endocrine clinic were evaluated for signs and symptoms of vitamin B12 deficiency. Laboratory parameters including Haemoglobin (Hb), MCV, Vitamin B12 levels and ...