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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.ical labeling reveals the genome-wide distribution of 5-hydrox-ymethylcytosine. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function...
Alkylating agents, topoisomerase II inhibitors, ionizing radiation, and other hematotoxins induce DNA damage in hematopoietic stem cells that results in lesions such as balanced and unbalanced chromosome rearrangements, -5/del(5q) and/or -7/del(7q), as well as other submicroscopic genetic lesions. Together with epigenetic alterations, these result in dysplasia, clonal expansion, and ultimately ...
Up to 85% of adult patients with AML achieve complete response (CR) using current standard regimens and depending on pre-treatment characteristics. However, only ∼25–45% have a long-term leukemia-free survival depending their age and leukemia features. A number of clinical features such as age, performance status, organ dysfunction, and biological characteristics of the disease (most importantl...
The cadherin gene FAT1, located on chromosome 4q34-35 (ref. 1) within a region frequently deleted in human cancers, encodes a large protein with 34 extracellular cadherin repeats. In solid tumors, aberrant expression of FAT1 was found to be associated with disease progression. Although the gene was originally cloned from a human T-cell acute lymphoblastic leukemia (T-ALL) cell line, FAT1 just r...
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