Disseminated Bacillus Calmette-Guerin (BCG) infection after innoculation of live vaccine is considered to result from impaired immunity. However, in half of the cases, regarded as idiopathic, no well-defined immunodeficiency condition can account for the infection. The objective of this study was to report the prevalence, clinical features, associated infections, and outcome of children with id...

Dear Editor, Since 1976 Bacillus Calmette-Guerin (an attenuated form of wild type Mycobacterium bovis; BCG) has been extensively used for the treatment of superficial bladder cancer. It is a safe and well tolerated treatment with rare adverse events including allergic reactions, granoulomatous prostitidis or epididymo-orchitis, disseminated infection and BCG sepsis1. Although cystitis is not an...

For treating patients with superficial bladder cancer and a moderate-to-high risk of tumor recurrence or progression, intravesical BCG has been the key development of the last generation. However, BCG has also brought with it a novel set of challenges. An understanding of when, to whom, and how BCG should be given is critical if optimal outcomes are to be achieved. This article the authors revi...

Presented here is the case of a nine-month-old boy with the osteomyelitis of the upper area sternum caused by bacillus Calmette-Guerin (BCG), the Danish 1331 strain vaccine against tuberculosis. Upon examination, a swelling of approximately 2×3 cm diameter was observed in the upper sternal area. The mass was hard, fixed and sensitive to palpation with no local skin hyperaemia. Chest X-rays reve...

Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 13, No. 5, May 2007 799 Jennifer Cuellar-Rodríguez,* Arturo Galindo-Fraga,* Víctor Guevara,* Carolina Pérez-Jiménez,* Luis Espinosa-Aguilar,* Ana Lilia Rolón,* Araceli Hernández-Cruz, * Esaú López-Jácome,* Miriam Bobadilla-del-Valle,* Areli Martínez-Gamboa,* Alfredo Ponce-de-León,* and José Sifuentes-Osornio* *Instituto Nacional de Ciencias ...

Bacillus Calmette-Guérin (BCG) related regional lymphadenitis is not an uncommon complication following BCG vaccination. We present a case series of 11 infants with suppurative BCG lymphadenitis managed in Hospital Authority Infectious Disease Centre of Hong Kong over a 5-year period. All of them presented with isolated left axillary mass which suppurated at a mean of 3.5 months (range 2 to 5 m...

When it comes to the treatment of patients with non-muscle-invasive bladder cancer (NMIBC) intravesical bacillus Calmette-Guérin (BCG), two questions must be considered: 1) what dose give, and 2) for how long? The issue optimal duration has been subject several randomized trials is especially pertinent in context a global BCG shortage. Despite this, there appears uncertainty as whether or may c...

granulomatosis and hypercalcaemia following intravesical bacillus CalmetteGuérin immunotherapy. J Intern Med. 2002;251:272–277. 4. Buchs N, Chevrel G, Miossec P. Bacillus Calmette-Guérin induced aseptic arthritis: an experimental model of reactive arthritis. J Rheumatol. 1998;25:1662–1665. 5. Mas AJ, Romera M, Valverde Garcia J. Articular manifestations after the administration of intravesical ...

2014 Bacillus Calmette-Guérin (BCG) is a vaccine derived from attenuated strains of Mycobacterium bovis. Mycobacterium bovis BCG-based therapy is considered an effective alternative for bladder carcinoma in situ when exclusive transurethral resection is inadequate. Among the complications associated with therapy, there are few reports in the literature on reactive arthritis. We report the case ...

Three different cultures of BCG propagated for over 2 years in a liquid medium containing Tween 80 and albumin were found to differ in several of their intrinsic properties. Cultures of the three strains were found to consist of morphologically heterogeneous populations-each culture being made up of three main colonial types-spreading, intermediate, and non-spreading. The percentage distributio...