Asthma is characterized by chronic inflammation, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration into the lungs. In this study, we examined the effects of baicalein, wogonin, and Scutellaria baicalensis ethanol extract on ovalbumin (OVA)-induced asthma by evaluating Th1/Th2 cytokine levels, histopathologic analysis, and compound 48/80-induced s...

Epidemiologic and systematic studies have indicated that flavonoid consumption is associated with a lower incidence of breast cancer. Baicalein is the primary flavonoid derived from the roots of Scutellaria baicalensis Georgi. In the current study, the long-term exposure of breast epithelial cells to 17β-estradiol (E2) was used to investigate the chemopreventive potential of baicalein on neopla...

BACKGROUND Dengue is a serious arboviral disease currently with no effective antiviral therapy or approved vaccine available. Therefore, finding the effective compound against dengue virus (DENV) replication is very important. Among the natural compounds, bioflavonoids derived mainly from plants are of interest because of their biological and medicinal benefits. METHODS In the present study, ...

Our study explores the antioxidant and cytoprotective effects of baicalein and further discusses the possible mechanisms. A methyl thiazolyl tetrazolium (MTT) assay revealed that baicalein could considerably enhance the viability of hydroxyl radical-treated bone marrow-mesenchymal stem cells (bmMSCs) at 37-370 µM. The highest viability rate was 120.4%. In subsequent studies, baicalein was obser...

BACKGROUND Baicalein, a bioflavone present in the dry roots of Scutellaria baicalensis Georgi, is known to reduce eotaxin production in human fibroblasts. However, there are no reports of its anti-asthma activity or its effect on airway injury. METHODOLOGY/PRINCIPAL FINDINGS In a standard experimental asthma model, male Balb/c mice that were sensitized with ovalbumin (OVA), treated with baica...

Background: An association has been reported between hepatitis and glycogen storage problems. Glycogen disease (GSD) type I is induced by G6PD deficiency. Silymarin baicalein, as herbal agents, have hepatoprotective antioxidant potentials. Objectives: In this study, we assessed the effects of these herbs on liver problems hepatitis. Methods: Twenty male rats kept under standard laboratory condi...

Cancer is one of the leading causes of death worldwide and a major global health problem. In recent decades, the rates of both mortality and morbidity of cancer have rapidly increased for a variety of reasons. Despite treatment options, there are serious side effects associated with chemotherapy drugs and multiple forms of drug resistance that significantly reduce their effects. There is an acc...

Using rat liver mitochondria as model systems, we examined the radioprotective and antioxidant effects of the Indian medicinal plant Terminalia arjuna. Various sohxlet fractions of the bark and the medicinal formulation arjunsal besides an active ingredient, baicalein, were examined for their ability to protect both rat liver mitochondria and cardiac homogenate against radiation and oxidative s...

In both type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by an inadequate mass and progressive dysfunction of β-cell, leading to the impaired insulin secretion. Here, we show that dietary supplementation of baicalein, a flavone isolated from the roots of Chinese herb Scutellaria baicalensis, improved glucose tolerance and enhanced gluco...

The present study aimed to investigate the anti-inflammatory effects of Baicalein on human osteoarthritic chondrocytes and its molecular mechanisms, explore related events that may occur. extracted were stimulated with interleukins. After administered different concentrations Baicalein, survival rate was observed. Apoptosis detected by apoptosis assay kit. effect NO production using Griess reag...