Investigations of the interference by other substances in the detection and determination of barbiturates in biological materials are described.

The currently accepted explanation of the short action of barbiturate anesthetics is that the redistribution of drug within the body compartments and also some degree of metabolism being involved. It is, however manifestly evident that the barbiturates anesthetic are not rapidly metabolized. Thus it was assumed that molecular modifications could provide barbiturates which undergo rapid metaboli...

Automated methods are described for extracting drugs from urine and for subsequently detecting them by ultraviolet or visible absorptiometry, or by spectrofluorometry. Standard Technicon AutoAn#{225}lyzer quipment has been adapted for use in the extraction processes; and manifolds for barbiturates, morphine, and bases are described. For drugs extracted from urine, the limits of detection were 2...

Pharmaceuticals are considered emerging contaminants in terms of impacts on wildlife. One chemical group concern is euthanasia agents used veterinary medicine. Here we present data the occurrence barbiturate intoxication using samples collected from 2004 to 2020 suspected wildlife and domestic animal poisoning cases Spain (n = 3210). Barbiturate was seen 3.4% (45/1334) total number confirmed in...

Patients with alcohol‐associated hepatitis (AH) who are hospitalized may be treated intravenous benzodiazepines for alcohol withdrawal; this is standard in the U.S. However, a new study has found that and barbiturates associated mortality such patients recommends monitoring, chlomethiazole, an oral thiamine derivative given universally to prophylactically, instead. Monitoring withdrawal can the...

Availability of drugs with high lethality has been hypothesized to increase the risk of self-poisoning suicides. A literature search concerning deliberate self-poisoning and the effect of restricting access to drugs was conducted, and the effect of restrictions in availability of barbiturates, tricyclic antidepressants, dextropropoxyphene, and weak analgesics was reviewed. The correlations betw...