نتایج جستجو برای: basal core promoter double mutations
تعداد نتایج: 780868 فیلتر نتایج به سال:
BACKGROUND Studies focused on the correlation of mutations in the genome of Hepatitis B Virus (HBV) like Pre-S mutation, Basal Core promoter (BCP), Enhancer II (EnhII), especially Precore mutation, with the risk of hepatocellular carcinoma (HCC) have triggered stiff controversies. With an increasing number of studies in this field recently, we conducted this meta-analysis to appraise the correl...
Transcriptional regulation is pivotal for development and differentiation of organisms. Transcription of eukaryotic protein-coding genes by RNA polymerase II (Pol II) initiates at the core promoter. Core promoters, which encompass the transcription start site, may contain functional core promoter elements, such as the TATA box, initiator, TCT and downstream core promoter element. TRF2 (TATA-box...
Results The mean age of patients was 44 ± 12.2. Most of them were HBeAg negative (90%). The mean HBV DNA was 475104 ± 160591 UI/mL. Phylogenetic analysis identified 90% isolates in genotype D and 10% in genotype A. Most genotypes D isolates belonged to subgenotype D7 (80%) followed by subgenotype D1 (25%) and one isolate belonged to subgenotype D2. All genotype A strains belonged to subgenotype...
The rat Na(+)/H(+) exchanger isoform-2 (NHE-2) gene promoter lacks a TATA box and is very GC rich. A minimal promoter extending from bp -36 to +116 directs high-level expression of NHE-2 in mouse inner medullary collecting duct (mIMCD-3) cells. Four Sp1 consensus elements were found in this region. The introduction of mutations within these Sp1 consensus elements and DNA footprinting revealed t...
This study was carried out to determine the effects of hepatitis B virus genotypes, core promoter mutations (A1762G1764-->T1762A1764) as well as precore stop codon mutations (TGG-->TAG) on HBeAg expression and HBeAg/ anti-HBe status. Study was also performed on the effects of codon 15 variants (C1858/ T1858) on the predisposition of precore stop codon mutations (TGG-->TAG). A total of 77 sera s...
current investigations indicate different in vitro infection patterns for oka and dumas strains. infection of cells in culture with dumas strain produces lower number of infectious particles while the oka strain is highly infectious in vitro. it is postulated that weak expression of the replication genes in dumas strain may be the reason for the attenuated phenotype. the objective of this stud...
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