Software systems nowadays are becoming increasingly complex and vulnerable to all sorts of failures and attacks. There is a rising need for robust self-repairing systems able to restore full functionality in face of internal and external perturbations, including those that affect their own code base. However, it is difficult to achieve code self-repair with conventional programming models. We p...

LO81 MODELS FOR THE ACTIVE SITES IN THE MANGANESE CATALASE, OXYGEN EVOLVING COMPLEX AND VANADIUM BROMOPEROXIDASE. V.L. Pecoraro, X. Li, J.A. Bonadies, MS. Lab, E. Larson and S. Saadeh, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-I 055, USA. Schiff Base and a-hydroxy acid complexes of manganese will be presented as models for the spectroscopic and reactivity behavior of ...

Shape-persistent conjugated macrocycles are challenging synthetic targets with interesting properties and potential for a number of applications. In contrast to the standard kinetic approaches to macrocycles, reversible Schiff-base condensation offers a one-step, thermodynamic route to large macrocycles. These macrocycles, which feature “salen”-type coordination environments and an interior tha...

The stability of the retinal chromophore attachment varies between different visual pigments and may factor in some retinal disease states. Opsin appears to stabilize this Schiff base linkage by: (i) affecting the hydrolysis chemistry, (ii) shielding the retinal linkage from solvent, or (iii) acting as a kinetic trap to slow retinal release. Here we describe methods to determine Schiff base sta...

an organosuperbase (n,n-dimethylbiguanide) immobilized on mesoporous and magnetically separable silica supports, was found for the first time, to act as a highly-stable, scalable and efficient heterogeneous catalyst for the henry reaction under mild and neutral condition. several factors such as catalyst amount, solvent and reaction time concerning the reactivity were also discussed. the proced...

The history of assessing the acid-base equilibrium and associated disorders is intertwined with the evolution of the definition of an acid. In the 1950s clinical chemists combined the Henderson-Hasselbalch equation and the Bronsted-Lowry definition of an acid to produce the current bicarbonate ion-centred approach to metabolic acid-base disorders. Stewart repackaged pre-1950 ideas of acid-base ...

There are many examples of protein cages in nature, from the outer capsid shells viruses that protect their genetic material, to simple organelle-like structures bacteria house enzymes within interior. This Account serves introduce world a chemical audience, and highlight similarities concepts supramolecular chemistry, revealing how knowledge base chemistry can provide foundation for valuable i...

The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5', C-1', and C-4' positions of deoxyribose on each strand. In a dodecamer oligodeoxyribonucleotide containing the sequence AGC.GCT, a bistranded lesion staggered two nucleotides in the 3' direction, is generated that consists primarily of an abas...