Most batch pharmaceutical fermentations have successive phases of operation. Detection of process phase landmarks is important for improving the performance of process monitoring and control. This study considers techniques for adjustment of batch data lengths to match landmarks of phases during the progress of the batch. Time synchronization and landmark alignment techniques are presented and ...

Batch processes are becoming more and more important in the chemical process industry, where they are used in the manufacture of specialty materials, which often are highly profitable. Some examples where batch processes are important are the manufacturing of pharmaceuticals, polymers, and semiconductors. The focus of this thesis is exception handling and fault detection in batch control. In th...

Because the different batch of batch processes has different raw materials and changeable control conditions, measurement data may lead to drift and it’s difficult to obtain complete sampling data at any time during the reaction process. So a multi-way kernel T-PLS (MKT-PLS) algorithm was proposed to improve the fault diagnosis accuracy of batch processes. This algorithm firstly unfolds three d...

Introduction: Note taking while attending a PPT requires highactivity of memory and writing process which ultimately leadsto what is called “death by power point” referring to boredomand fatigue. To overcome this we planned to evaluate the impactof utilisation of uncompleted handouts given prior to PPTpresentations.Methods: Final year MBBS students were divided in 2 batches,batch A and batch B....

Batch processes are commonly characterized by uneven trajectories due to the existence of batch-to-batch variations. The batch end-product quality is usually measured at the end of these uneven trajectories. It is necessary to align the time differences for both the measured trajectories and the batch end-product quality in order to implement statistical process monitoring and control schemes. ...

Run-to-Run (R2R) control has been widely used in semiconductor manufacturing to compensate for process disturbance and to improve quality. The traditional R2R controller only takes the process output in a previous run as its input and generates an optimal recipe for the next run. In a multistage semiconductor manufacturing process, variations in upstream stations are propagated to downstream st...

The issues of waste generation in batch process plants differ in many aspects from those in continuous plants. Despite the smaller-scale of processing, complexities from discontinuities and run-to-run variations make waste minimization in batch plants more challenging. In this paper, we introduce an integrated qualitative-quantitative methodology and decision support system, called Batch-ENVOPE...

Cephalosporin C (CPC), a β-lactam antibiotic, is starting molecule for industrial production of semi synthetic cephalosporins. CPC fermentation has been carried out in Air Lift Reactor (indigenously made up of borosilicate glass) in different fermentation modes i.e., batch and fed batch modes using a mold Acremonium chrysogenum (synn. Cephalosporium acremonium). A definite correlation exists be...