OBJECTIVES The HER-2/neu oncogene is overexpressed in many types of cancer and especially in 25% to 30% of breast cancers. Single reports mention HER-2/neu positivity in hematological malignancies like Hodgkins's disease and even diffuse large-cell lymphoma. OBJECTIVE To test for HER-2/neu overexpression in patients with non-Hodgkin's lymphoma and the possible role of the recombinant monoclon...

Purpose: Lymphocytic infiltration of tumors predicts improved survival in patients with breast cancer. Previous studies have suggested that this survival benefit is confined predominantly to the basal-like subtype. Immune infiltration in ovarian tumors is also associated with improved prognosis. Currently, it is unclear what aspects of the immune response mediate this improved outcome. Experime...

a 45-year-old female patient with a diagnosis of ulcerative colitis complicated with composite lymphoma in the spleen and para-aortic lymph node presented with a one-month history of malaise, weakness and fatigue. only mesalamine kept ulcerative colitis under control. in physical examination, splenomegaly was revealed and pancytopenia was obtained from laboratory data. computed tomography scan ...

a case of primary malignant non-hodgkin's lymphoma of the breast is reported. this is the first well-documented case of breast lymphoma in our institution and also in iran. the diagnosis of primary breast lymphoma requires the presence of lymphomatous infiltration in close ass, tissue in patients with neither previous lymphoma nor concurrent lymphoma in another site. there is no definite c...

In a recent review of the transcription control of hematopoiesis, Shivdasani and Orkin’ comment that the POU domain transcription factor, Oct-2, is expressed primarily in B lymphocytes. In another report in the same issue of Blood, Bargou et al* report on the consistent expression of Oct-2 in Reed-Sternberg cells of Hodgkin lymphoma, a lineage of cells with variable expression of markers of B-c...

background: burkitt’s lymphoma is a high grade b-cell neoplasm, which is a kind of small non-cleaved cell lymphoma . it is presumably the fastest growing human malignancy, and the patients are prone to develop tumor-lysis syndrome. here we present findings on our patients with burkitt lymphoma . materials and methods: this descriptive retrospective study included 46 children with abdominal burk...

burkitt lymphoma of stomach is among the most rapidly growing gastric cancersassociated with several gasterointestinal  symptoms  including  hematemesis,  anorexia,  vomiting  and  etc. gastric perforation  in patients with burkitt lymphoma of stomach is a very rare condition especially after chemotherapy. we herein present a 21-year old man who was kwon case of gastric burkitt lymphoma who had...

abstract background: primary cardiac lymphoma is extremely rare. case report: in this care report, we present the case of a 46-year-old man with primary cardiac lymphoma involving left atrium and interatrial septum, presenting as dyspnea palpitation and irregular heart beat. the diagnosis was obtained by transthoracic echocardiography and surgical biopsy with subxiphoid approach which revealed ...

Primary small intestinal malignancies are rare and accounting for 1-2% of all gastrointestinal (GIT) tumors. Extranodal lymphomas most commonly found in GIT with majority sites stomach, intestine ileo-cecal junction. Non-Hodgkin’s Lymphoma (NHL) predominantly B cell type constituting 90% cases few T type. The purpose this editorial is to highlight the morphology rarity lymphoma encountered jeju...

primary colorectal lymphoma (pcl) is a rare condition that accounts for a small percentage of all gastrointestinal (gi) malignancies. there are several reports in the literature regarding the most common features of pcl. however, primary lymphoma in the rectosigmoid junction has been rarely reported. our case was a 67-year-old male who presented with non-specific symptoms of bowel obstruction w...