A cross-sectional study was conducted in April-June 1992 at the outpatient clinic of the Robert Reid Children's Hospital in Santo Domingo to assess BCG vaccination coverage and factors affecting BCG vaccination of children. A consecutive sample of 2,000 patients under 18 years of age was included in the study. The person accompanying the patient to the hospital was interviewed, using a standard...

BCG uptake among infants in England has not been measured since targeted infant vaccination replaced universal schoolchildren vaccination in 2005, mainly because of the challenges in defining denominators. We estimated uptake between 2006 and 2008 by dividing number of BCG doses administered to infants by number of all live births (where BCG vaccination is universal) or ethnic minority/Eastern ...

OBJECTIVES To critically assess the prevalence among schoolchildren 6 to 9 years of age throughout the Dominican Republic of a bacille Calmette-Guérin (BCG) vaccination scar, and to examine the relationship between nutritional and sociodemographic factors and the likelihood of having a BCG scar. METHODS This correlational study used the database of the Second National Census on Height and Wei...

CONTEXT The duration of protection from tuberculosis of BCG vaccines is not known. OBJECTIVE To determine the long-term duration of protection of a BCG vaccine that was previously found to be efficacious. DESIGN Retrospective record review using Indian Health Service records, tuberculosis registries, death certificates, and supplemental interviews with trial participants. SETTING AND PART...

Wildlife reservoirs of Mycobacterium bovis represent serious obstacles to the eradication of tuberculosis in domestic livestock and the cause for many faltering bovine tuberculosis eradication programmes. One approach in dealing with wildlife reservoirs of disease is to interrupt inter-species and intraspecies transmission through vaccination of deer or cattle. To evaluate the efficacy of BCG v...

BACKGROUND While vaccination at birth with Mycobacterium bovis Bacilli Calmette-Guérin (BCG) protects against severe childhood tuberculosis, there is no consensus as to which components of the BCG-induced immune response mediate this protection. However, granulysin and perforin, found in the granules of cytotoxic T lymphocytes and Natural Killer (NK) cells, can kill intracellular mycobacteria a...

Nine of 355 cases of symtopmatic HIV-infected children who admitted to Chiang Mai University Hospital from January 1989 to December 1994 had complication due to BCG vaccination. The median age was 15 months with its range from 8 to 22 monts. Four cases presented with ulceration of the previously-healed BCG scar with ipsilateral enlarged and inflamed axillary nodes. Four cases had ipsilateral en...

BACKGROUND Bacillus Calmette-Guérin (BCG) vaccination possesses effects on health beyond its target disease, the so called "non-specific effects". We evaluate these effects, as well as the effect of timing of BCG and other vaccinations, on stunting in Sub-Saharan African (SSA) children under five. METHODS We use a Big Data design, including cross-sectional data for 368,450 children from 33 SS...

FEMALE GUINEA PIGS WERE SUBJECTED TO LAPAROTOMY AT DIFFERENT STAGES OF PREGNANCY, AND THEIR FETUSES INJECTED THROUGH THE UTERINE WALLS WITH ONE OF THE FOLLOWING PREPARATIONS: Old Tuberculin, tubercle bacilli of the BCG strain killed by heat or exposure to phenol, and living BCG. A large number of the animals injected in utero with Old Tuberculin failed to develop skin hypersensitivity to P.P.D....

This further report from Uganda of the re3ults of a trial of BCG vaccination against leprosy which was begun in 1960 and now has included more than 19,000 children, shows that among over 9000 unvaccinated children there were 174 cases of leprosy, whereas among a similar number given BCG vaccination there were only 27 cases. Thus, in these 2 comparable groups the attack rates per 1000 \Vere 19.3...