We have previously shown that sustained phosphatidylinositol (PI)-3 kinase activity is necessary for neurite outgrowth of PC12 cells induced by nerve growth factor (NGF). Microinjection of a constitutively active mutant of PI-3 kinase induced process formation suggesting that PI-3 kinase is indeed involved in the neurite outgrowth. However, the processes appeared to be incomplete neurites as th...

Monoclonal antibody 3F12 identifies a cytoplasmic antigen of 49 kDa in human hippocampus and neocortex. The distribution of 3F12 immunoreactive neurons closely matches that of Alzheimer's disease (AD) targeted neurons in these areas. In some hippocampal neurons of AD patients, this antigen colocalizes with ALZ-50, indicating the presence of AD pathology in these neurons. Molecular characterizat...

Long-distance migration is a strategy some animals use to survive a seasonally changing environment. To reach favorable grounds, migratory animals have evolved sophisticated navigational mechanisms that rely on a map and compasses. In migratory insects, the existence of a map sense (sense of position) remains poorly understood, but recent work has provided new insights into the mechanisms some ...

| In this paper we describe a vision-based mapping system for mobile robot navigation that is fast, simple and requires very modest computational resources. The system comes in two parts: a visual range subsystem and a map building subsystem. The visual range subsystem acts as a kind of `virtual range sensor': it takes as input a stream of images and produces as output a stream of range-and-bea...

Navigating animals need to know both the bearing of their goal (the 'map' step), and how to determine that direction (the 'compass' step). Compasses are typically arranged in hierarchies, with magnetic backup as a last resort when celestial information is unavailable. Magnetic information is often essential to calibrating celestial cues, though, and repeated recalibration between celestial and ...

Detecting defects, which is a branch of target detection in the field computer vision, widely used factory production. To solve problems existing algorithms that relate to their insensitivity large or medium defect targets on bearing covers, difficulty detecting subtle defects effectively and lack real-time detection, this work, we establish large-scale bearing-cover dataset propose an improved...

Full spectrum and holospectrum are homogenous information fusion technology developed for the fault diagnosis of rotating machinery, which is extensively exploited in analysis orbits rotor-bearing systems. However, they not adapted non-stationary signals, nor can be used vibrations multiple bearing sections. By drawing inspiration from multivariate variational mode decomposition (MVMD) complex-...

The intracellular signaling pathways mediating the neurotrophic actions of pituitary adenylate cyclase-activating polypeptide (PACAP) were investigated in human neuroblastoma SH-SY5Y cells. Previously, we showed that SH-SY5Y cells express the PAC(1) and VIP/PACAP receptor type 2 (VPAC(2)) receptors, and that the robust cAMP production in response to PACAP and vasoactive intestinal peptide (VIP)...

| In this paper we describe a vision-based mapping system for mobile robot navigation that is fast, simple and requires very modest computational resources. The system comes in two parts: a visual range subsystem and a map building subsystem. The visual range subsystem acts as a kind of`virtual range sensor': it takes as input a stream of images and produces as output a stream of range-and-bear...