The Nano-CrY zeolite synthesized and characterized by Fourier transfer infrared (FT-IR), X-ray diffraction (XRD),and Scanning electron microscopy (SEM).The result show that nano catalyst prepared with mainly particles size about 30-80 nm .The XRD show the structure of the zeolite does not collapse. This Nano-CrY zeolite has been used as new, and nontoxic catalyst for catalyzes of synthesis of 2...

Cancer is a leading cause of death worldwide. Many heterocyclic cores are present in the structures of clinically approved anticancer drugs. Meanwhile, benzothiazoles have been reported as one of the most important heterocyclic scaffolds in previously reported anticancer agents in the literature. Therefore, in this report, a novel series of 2-phenyl benzothiazole derivatives was synthesized, bi...

We report the synthesis of a series of aryl- or alkyl-substituted 2-mercaptobenzothiazoles by direct thiolation of benzothiazoles with aryl or alkyl thiols via copper-mediated aerobic C-H bond activation in the presence of stoichiometric CuI, 2,2'-bipyridine and Na(2)CO(3). We also show that the approach can be extended to thiazole, benzimidazole, and indole substrates. In addition, we present ...

NPP3 inhibitors are promising therapeutic agents due to their potential as anti-cancer, anti-metastatic and anti-neurodegenerative drugs. We have identified the first potent and selective inhibitors of human NPP3. We have also estimated the biochemical properties of the main NPP family members that can hydrolyse nucleotides using p-nitrophenyl-5'-thymidine monophosphate as substrate. Km values ...

cial problems affecting the skin and nails, to deeply invasive and disseminated infections, such as systemic candidiasis and pulmonary aspergillosis. These illnesses reduce the quality of life of patients and can progress to become life threatening. Four classes of antifungal drugs are available at present: polyene macrolides, azoles, flucytosine and candins. However, their use is restricted by...