Background: Neonatal hyperbilirubinemia is indeed common. However, severe nerve injuries and bilirubin encephalopathy are rare and only occur in the unusual cases of extreme hyperbilirubinemia. Objectives: To investigate brain magnetic resonance imaging (MRI) changes and their correlations with perinatal predisposing factors in neonates with indirect hyperbilirubinemia, via regions of interest ...

OBJECTIVE The objective of this study was to define the minimum academic content required for pediatricians to recognize the risk of kernicterus. METHODS A questionnaire was developed on the basis of American Academy of Pediatrics guidelines seeking to develop a consensus for pediatricians in training on the theoretical content about neonatal hyperbilirubinemia. To validate the instrument, we...

A 56-year-old woman was admitted to our hospital with jaundice, massive ascites, hepatic encephalopathy and an intramuscular hematoma. She had severe liver dysfunction with a total bilirubin level of 9.0 mg/dL, indirect bilirubin level of 6.9 mg/dL, albumin level of 2.8 g/dL and prothrombin ratio of 43%. Her hemoglobin level was 6.8 g/dL, and a peripheral blood smear showed the presence of a la...

The efficacy of methylprednisolone (1 g daily for three days), which is effective in reversing transplant rejection, was assessed in a randomised controlled trial of 55 patients with severe acute alcoholic hepatitis, 34 of whom had encephalopathy. The clinical progress, frequency of bleeding and sepsis, and cause of death were similar in the treatment (27 patients) and control groups (28 patien...

Unconjugated bilirubin (UCB) encephalopathy is a predominantly early life condition resulting from the impairment of several cellular functions in the brain of severely jaundiced infants. However, only few data exist on the age-dependent effects of UCB and their association with increased vulnerability of premature newborns, particularly in a sepsis condition. We investigated cell death, glutam...

We present a prospective case-control study of 27 serologically confirmed dengue hemorrhagic fever (DHF) patients with severe central nervous system symptoms. Dengue associated encephalopathy accounted for 0.5% of 5,400 patients admitted with DHF. The mortality rate among children with encephalopathy was 22%, with the survivors experiencing a complete recovery. Liver enzymes and bilirubin were ...

Abstract Background Decompensated liver disease (DCLD) has high mortality, and its prediction is important to prognosticate prioritize patients for transplantation. MELD, MELD variants, CTP were widely tested mortality with few drawbacks. The aim of the study propose a new prognostic model DCLD which better than existing scores. Materials methods Retrospective 321 enrolled. Patient relatives te...

We are reporting a rare case of hemolytic disease of newborn with weak D antigen in child. A 3rd order male child of G3P3A0 mother was admitted at 8th h of life with jaundice. Blood group of both mother and child were A Rh D negative. Baby's direct coombs test was positive. Weak D antigen was positive in baby. Hematological parameters showed all the signs of ongoing hemolysis, and the bilirubin...