Neurogenesis in the mammalian adult brain is a well established phenomenon (for the recent reviews see Carpentier & Palmer, 2009; Kaneko & Sawamoto, 2009; Rodriguez & Verkhratsky, 2011) that is important in both young and aging brain (Galvan & Jin, 2007; Rao et al., 2006). The subventricular zone, subgranular layer of the dentate gyrus (DG), and cortex are the main sites of adult neurogenesis (...

how to cite this article: mansouri nejad se, yazdan panah mj, tayyebi meibodi n, ashrafzadeh f, akhondian j, beiraghi toosi m, eslamieh h. griscelli syndrome: a case report. iran j child neurol. 2014 autumn;8(4): 72-75. objective griscelli syndrome (gs) is a rare autosomal recessive immune deficiency disorder that presents with pigmentary dilution of the skin and hair, recurrent skin and pulmon...

We read with interest the recent publications by Ariyoshi et al. (2011) and Raccor et al. (2011). The role of a number of cytochrome P450 (P450) isozymes in the 4-hydroxylation of cyclophosphamide has been debated for several years. There is evidence that both CYP2B6 and CYP2C19 are important in the biotransformation and activation of this prodrug in vitro (Chang et al., 1993, 1997; Huang et al...

Regarding our article on the association of androgen deprivation therapy (ADT) with increased Alzheimer’s disease risk, Bowen et al, Froehner and Wirth, Leow et al, and Brady et al highlight a number of significant considerations that will prove important in the design of future studies that investigate the association of ADT and Alzheimer’s disease. We agree with Bowen et al and Leow et al tha...

how to cite this article: inaloo s, haghbin s. multiple sclerosis in children. iran j child neurol. 2013 spring;7(2):1-10.   multiple sclerosis (ms) is the most important immune-mediated demyelinated disease of human which is typically the disease of young adults. a total of 4% to 5% of ms population are pediatric. pediatric ms is defined as the appearance of ms before the age of sixteen. about...

Human induced pluripotent stem cells (iPSCs) hold unprecedented potential to model human development and genetic disorders due to their capability to self-renew and differentiate into any somatic cell type. In the year of 2011, a number of iPSC disease models have been successfully developed for studying the mechanism of human diseases as well as establishing platforms for drug screening and te...