This paper investigates the development of basic cognitive, motor and noncognitive abilities from infancy to adolescence. We analyse the predictive power of these abilities, initial risk conditions and home resources for children’s achievement. Our data are taken from the Mannheim Study of Children at Risk (MARS), an epidemiological cohort study, which follows the long-term outcome of early ris...

Background: Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with an ultra-high risk of developing Alzheimer’s disease. However, there is individual variability in the onset of clinical dementia and in baseline cognitive abilities prior to decline, particularly in memory, executive functioning, and motor coordination. The LonDownS Consortium aims to de...

BACKGROUND Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with an ultra-high risk of developing Alzheimer's disease. However, there is individual variability in the onset of clinical dementia and in baseline cognitive abilities prior to decline, particularly in memory, executive functioning, and motor coordination. The LonDownS Consortium aims to det...

A single molecule of the "two-headed" motor enzyme kinesin can move along a microtubule continuously for many enzymatic turnovers (processive movement), and the velocity produced by one kinesin molecule is the same as that produced by many kinesin molecules (high duty ratio). We studied the microtubule movement driven at 1 mM ATP by biotinated N-terminal fragments of Drosophila kinesin heavy ch...

This article is a review of the nature of motor control: the abilities and limitations of the body, the principles of doing and learning, how parts of the nervous system interact, and how information is processed to generate the blend of sensory, perceptive, and motor functions that we call motor control. The relation to physical therapy is stressed: PT is regarded as an emerging applied scienc...

Binocular vision disorders (BVD) are quite common in subjects with cerebellar dysfunctions. Also individuals with strabismus often suffer from many motor deficits, such as impaired body balance and walking. It is known that the cerebellum is necessary to maintain proper body posture but also to learn motor skills. It is conceivable that subjects with BVD would also have deficits in procedural (...

We explore a biologically plausible deep reinforcement learning system by feeding it the human observations of the experiment world. The main hypothesis is that the more similar our learning model with the actual human learning model is, the better the performance should be. We examine this idea by using the AuGMEnT deep neural network which is a bio-plausible reinforcement system with a focus ...

This paper presents a molecular mechanics study using a molecular dynamics software (NAMD) coupled to virtual reality techniques for intuitive bio-nanorobotic prototyping. Using molecular dynamic simulations the operator can design, characterize and prototype the behavior of bio-nanorobotic components and structures. The main novelty of the proposed simulations is based on the characterization ...

This paper presents a molecular mechanics study using a molecular dynamics software (NAMD) coupled to virtual reality (VR) techniques for intuitive bio-nanorobotic prototyping. Using simulated bio-nano environments in VR, the operator can design and characterize through physical simulation and 3-D visualization the behavior of protein-based components and structures. The main novelty of the pro...

background: this study aimed to investigate the relationship between health related quality of life (hrqol), motor ability and weight status in children. methods: two hundred forty children ages 9-11 yr who were selected via multi stage cluster sampling design from primary schools in the shahre qods at tehran, iran in 2007. hrqol was assessed by the pediatric quality of life inventory (pedsql)....