Aging is a three-stage process: metabolism, damage, and pathology. The biochemical processes that sustain life generate toxins as an intrinsic side effect. These toxins cause damage, of which a small proportion cannot be removed by any endogenous repair process and thus accumulates. This accumulating damage ultimately drives age-related degeneration. Interventions can be designed at all three s...

Food intake is essential for maintaining homeostasis, which is necessary for survival in all species. However, food intake also impacts multiple biochemical processes that influence our behavior. Here, we investigate the causal relationship between macronutrient composition, its bodily biochemical impact, and a modulation of human social decision making. Across two studies, we show that breakfa...

The circular process model is a psychobiological model of depression, in which it is postulated that catecholamines and negative cognitions interact to influence depression. Since its publication, there have been no empirical tests to support or refute the model. This study tested the model in 92 depressed adult outpatients with non-bipolar non-psychotic depression. There were no significant bi...

The gene networks that comprise the circadian clock modulate biological function across a range of scales, from gene expression to performance and adaptive behaviour. The clock functions by generating endogenous rhythms that can be entrained to the external 24-h day-night cycle, enabling organisms to optimally time biochemical processes relative to dawn and dusk. In recent years, computational ...

Electron transfer may be concerted with proton transfer. It may also be concerted with the cleavage of a bond between heavy atoms. All three events may also be concerted. A model is presented to analyze the kinetics of these all-concerted reactions for homogeneous or electrochemical reduction or oxidation processes. It allows the estimation of the kinetic advantage that derives from the increas...

This paper presents a thermodynamic analysis of a biochemical process for the production of bioethanol from a lignocellulosic feedstock. The major inefficiencies in the process are identified as: i) the combustion of lignin for process heat and power production and ii) the simultaneous saccharification and fermentation process. As lignin is not converted to ethanol and lignin has a high value o...

Circadian rhythms, which occur spontaneously with a period of about 24 h in a variety of organisms, allow their adaptation to the periodic variations of the environment. These rhythms are generated by a genetic regulatory network involving a negative feedback loop on transcription. Mathematical models based on the negative autoregulation of gene expression by the protein product of a clock gene...

Natively unfolded regions have been shown to be common in functional proteins in a vast range of biochemical processes. In contrast to classical structural biology, unfolded proteins must be described by an ensemble of intermediate conformers. The traditional NMR approach, which has been widely used for structure determination in classical structural biology, is still feasible for the study of ...

Many natural fruits and vegetables adopt an approximately spheroidal shape and are characterized by their distinct undulating topologies. We demonstrate that various global pattern features can be reproduced by anisotropic stress-driven buckles on spheroidal core/shell systems, which implies that the relevant mechanical forces might provide a template underpinning the topological conformation i...

Organism and environment are in a state of constant interaction, and discourse is viewed as one form of manifestation of this interaction. Through the study of discourse insights can be gained into those components that bring about mental events. Verbal structure, communication of beliefs and action/interaction are highly interactive dimensions of discourse. Taking this perspective as a framewo...