The demand to get a tool for biological parameter estimation of new compounds for clinical application, supports the postulation of predictive models as an alternative to conventional classical assays being no necessary the use of experimentation in animals. A lot of in vitro systems, including the use of physicochemical parameters of drugs, the permeability data from cell culture line and the ...

A simple and rapid HPLC-UV method has been developed for determination of levofloxacin in human plasma. Chromatographic separation was performed on a Kromasil C18 column with the mobile phase consisting of acetonitrile, water, phosphoric acid and triethylamine (14:86:0.6:0.3, v/v/v/v) and flow rate was 1.0 mL/min. The method used ultraviolet detection set at a wavelength of 294 nm. The standard...

June 29, 2010 Version 2.5.3 Date 2010-06-25 Title Average bioequivalence and bioavailability data analysis tool Author Hsin-ya Lee, Yung-jin Lee Maintainer Yung-jin Lee Depends R (>= 2.10.0), reshape, nlme, sciplot, plotrix, ICSNP, gdata Description An average bioequivalence (ABE) and bioavailability data analysis tool including sample size estimation, noncompartmental anal...

    In this double blind crossover study we assessed the bioequivalence of 200 mg enteric coated sodium valproate tablets manufactured by Roozdarou with 200 mg enteric coated sodium valproate (Orlept) manufactured by Desitin, Germany. Twelve healthy male volunteers were administered a single dose of 600 mg sodium valproate manufactured by Roozdarou, followed by a similar dose of Orlept, 2 weeks...

Bioequivalence of two brands of gentamicin injection were studied in twelve clinically healthy goats. Single dose, equivalent to 5 mg gentamicin/kg.b.wt. was administered intramuscular to the subjects in a parallel two way crossover design. The studied non-innovator brand (Opigent 10%) were biologically equivalence with Garamicin 4% as innovator (no statistically significant difference were obs...

a sensitive and rapid method is described for determination of clopidogrel carboxylic acid (cca), the inactive metabolite of the antiplatelet agent clopidogrel in human serum. the analytical procedure involves liquid-liquid extraction of the analyte and an internal standard (phenytoin) with ethyl acetate. a mobile phase consisting of 0.05 m phosphate buffer containing triethylamine (0.5 ml/l; p...

Title Average bioequivalence and bioavailability data analysis tool Author Hsin-ya Lee , Yung-jin Lee Maintainer Hsin-ya Lee Description An average bioequivalence (ABE) and bioavailability data analysis tool including sample size estimation, noncompartmental analysis (NCA), ANOVA (lm) for a standard RT/TR 2x2x2 crossover design and...