Microarray technology is generating a massive amount of data that need to be studied with statistical approaches, clustered according to gene expression characteristics, and annotated with biological relevant information. Many web-based tools and databases have been created to annotate genes with biological information, classify genes in function-related families, and identify functional links ...

There is mounting evidence that traditional investigations are no longer sufficient either to assess the ecological characteristics of a resource or to better understand the dynamics of an ecosystem. Reliable experimental data to be used for further investigation as well as for environmental corrective action are obtained using the traditional quantitative and qualitative biological methods. In...

Novel atomic level AI topological indexes based on the adjacency matrix and distance matrix of a graph is used to code the structural environment of each atomic type in a molecule. These AI indexes, along with Xu index, are successfully extended to compounds with heteroatoms in terms of novel vertex degree v(m), which is derived from the valence connectivity delta(v) of Kier-Hall to resolve the...

Title of Document: SMOKING AND NEUROPHYSIOLOGICAL MARKERS OF INFORMATION PROCESSING IN SCHIZOPHRENIA Alice M. Saperstein, M.A., 2006 Directed By: Professor Jack J. Blanchard, Ph.D., Department of Psychology The primary aim of this study was to compare patterns of nicotine consumption among patients with schizophrenia and a matched community control sample. Assessments included self-report and b...

BACKGROUND Identifying drug targets is a critical step in pharmacology. Drug phenotypic and chemical indexes are two important indicators in this field. However, in previous studies, the indexes were always isolated and the candidate proteins were often limited to a small subset of the human genome. METHODOLOGY/PRINCIPAL FINDINGS Based on the correlations observed in pharmacological and genom...

OBJECTIVES to assess environmental and biological monitoring of exposure to organic solvents in a glue-manufacturing company in Sfax, Tunisia. METHODS Exposure of volunteer workers, in the solvented glue-work-stations, in the control laboratory and in the storage rooms of the finished products, was assessed through indoor-air and urine measurements. Informed consent of the workers was obtaine...

We are living in a fast-changing world promoted by anthropogenic actions and ecosystems’ functioning has been constantly changed. One example is the globally reduction of river flow that can lead to more than 50% rivers streams around becoming intermittent. However, relationship between environmental changes biological communities limited taxonomic approach, rather functional approach. Function...

MOTIVATIONS Classification of biological samples for diagnostic purposes is a difficult task because of the many decisions involved on the number, type and functional manipulations of the input variables. This study presents a generally applicable strategy for systematic formulation of optimal diagnostic indexes. To this end, we develop a novel set of computational tools by integrating regressi...

With economic growth and the improvement of the urbanization level, human activities have constantly interfered with landscape patterns, resulting in serious threats to regional ecological security. Therefore, it is of great significance to study the evolution and optimization of the landscape patterns. Based on three TM images from 1990, 2000, and 2010, and selected landscape pattern indexes, ...

Data analysis and interpretation require intellectual frameworks, and to share the results in a community, scientific bases are preferred for the framework. A variety of indexes have been used for interpreting distances between transcriptome data, however, such indexes always lack necessity since they have been derived for non-biological purposes and their appropriateness have not been verified...