BACKGROUND Flavonoids are bio-active specialized plant metabolites which mainly occur as different glycosides. Due to the increasing market demand, various biotechnological approaches have been developed which use Escherichia coli as a microbial catalyst for the stereospecific glycosylation of flavonoids. Despite these efforts, most processes still display low production rates and titers, which...

AMA Wybrańczyk Ł, Brudzińska A, Jarosz-Chobot P, Deja G. Glucose management indicator – potential factors affecting differences in comparison with HbA1c and clinical significance of this phenomenon. Pediatric Endocrinology Diabetes Metabolism. 2023. doi:10.5114/pedm.2023.130028. APA Wybrańczyk, Ł., Brudzińska, A., Jarosz-Chobot, P., & Deja, (2023). https://doi.org/10.5114/pedm.2023.130028 Chica...

Background & Objective: In traditional medicine, leaves of white mulberry (Morus alba L.) are used as antidiabetic agents. Considering the presence of flavonoids, this plant exhibits insulin mimetic activities. Nesfatin-1 is described as an anorexigenic regulatory peptide, which can influence glucose metabolism via insulin sensitivity enhancement. This study examined the effects of both mulberr...

Blood-based bioenergetic profiling provides a minimally invasive assessment of mitochondrial health shown to be related to key features of aging. Previous studies show that blood cells recapitulate mitochondrial alterations in the central nervous system under pathological conditions, including the development of Alzheimer's disease. In this study of nonhuman primates, we focus on mitochondrial ...

Osteocalcin, the second most abundant protein in bone tissue after collagen, is secreted by osteoblasts and thought to participate in mineralization and calcium ion homeostasis. In addition to its use as biomarker in ostoporosis, experimental studies on mice published in Cell journal revealed for osteocalcin new metabolic functions, as hormone, being involved in blood glucose regulation, in ins...

Recent discoveries have revealed that microRNAs (miRNAs) play a key role in the regulation of gene expression. In this review, we summarize the rapidly evolving knowledge about liver miRNAs (including miR-33, -33*, miR-223, -30c, -144, -148a, -24, -29, and -122) and their link to hepatic lipid metabolism, atherosclerosis and cardiovascular disease, non-alcoholic fatty liver disease, metabolic s...

UNLABELLED AKT (a serine/threonine-specific protein kinase) regulates many cellular processes contributing to cytotoxic drug resistance. This study's primary objective examined the relationship between GSK2141795, an oral, pan-AKT inhibitor, and (18)F-FDG PET markers of glucose metabolism in tumor tissue to determine whether (18)F-FDG PET could be used to guide personalized dosing of GSK2141795...