BACKGROUND The influence of stem cells and lentiviral expression of basic fibroblastic growth factor (bFGF) on tendon healing and remodelling was investigated in an in-vivo long-term (12 weeks) rat Achilles tendon defect model. METHODS In sixty male Lewis rats, complete tendon defects (2.4 mm) were created and either left untreated (PBS) or treated by injection of stem cells lentivirally expr...

Methods Young people aged between 8-14 were recruited from the rheumatology based Non-Inflammatory Musculoskeletal Pain Clinic at Great Ormond Street Hospital over a 12 month period. They were assessed using biomechanical measures (muscle strength and degree of hypermobility), sensory processing using Quantitative Sensory Testing and psychological measures of anxiety, depression and pain coping...

Spring 2013 | Volume 7 Columbia Undergraduate Science Journal 10 Characterizing the Biomechanical and Biochemical Properties of Mouse Uterine Tissue Eli Mondragon*, Kyoko Yoshida, M.S. Kristin Myers, Ph.D Biomedical Engineering Department, Columbia University, New York, NY 10027 Mechanical Engineering Department, Columbia University, New York, NY 10027 Abstract For a successful pregnancy, the u...

OBJECTIVE To biomechanically test the properties of three different Universal Micro External Fixator (UMEX™) configurations with regard to their use in very small animals (<5kg) and compare the UMEX system to the widely used IMEX External Skeletal Fixation (SK™) system in terms of stiffness, space needed for pin placement and weight. METHODS Three different UMEX configurations (type Ia, type ...

BACKGROUND Rotator cuff failure after surgery may be attributed to inferior tissue healing properties that result from repetitive cyclic loading during early rehabilitation. Enhancing the biological healing process may reduce the incidence of failures after rotator cuff repairs. HYPOTHESIS Augmentation of rotator cuff tissue using swine small intestine submucosa in a sheep model will improve ...

+DiStefano, J G; Park, A Y; Nguyen, T Q; Diederichs, G; Buckley, J M; Montgomery, W H 3 +San Francisco Orthopaedic Residency Program, San Francisco, CA; Biomechanical Testing Facility, UCSF/SFGH Orthopaedic Trauma Institute, San Francisco, CA; Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA; Department of Radiology, University of California San Franc...

PURPOSE Determine if balance and technique training (BTT) implemented adjunct to normal Australian football (AF) training reduces external knee loading during sidestepping. Additionally, the authors determined if an athlete's knee joint kinematics and kinetics change over a season of AF. METHODOLOGY Eight amateur-level AF clubs (n=1,001 males) volunteered to participate in either 28 weeks of ...

PURPOSE To evaluate several physical properties and physical dimensions of commercially available soft-tissue augmentation devices. METHODS After 2 x 5-cm strips of several graft materials were hydrated, load elongation, cyclic and permanent displacement, percent elastic displacement, tensile modulus, stiffness, and ultimate load-to-failure strength were determined. With a 5-N preload, 30 cyc...

PURPOSE To evaluate the anatomic, biomechanical, and histologic properties of the biceps vinculum and its potential role as a restraint to distal migration of the biceps after tenotomy. METHODS Eight human shoulders were dissected to define the anatomic parameters of the biceps vinculum. Histologic studies were performed by sectioning through the vinculum-tendon attachment and performing H&E ...