Background and Aims: This research is carried out with the aim of comparing anxiety, depression and global assessment of functioning between two groups of bipolar patients at mixed and manic episodes. Methods: Using an analytical cross-sectional approach, a sample of 94 patients with mean age of 32 years old (Standard Deviation: 11.3), who had been categorically diagnosed with bipolar disorder ...

BACKGROUND Highly hypnotizable individuals have impaired executive function, elevated motor impulsivity and increased emotional sensitivity, which are sometimes found in bipolar disorder patients. It is then reasonable to assume that certain aspects of hypnotic susceptibility differ with the types of bipolar disorder. METHODS The Stanford Hypnotic Susceptibility Scale: Form C (SHSS:C) test, t...

BACKGROUND Serious mental illnesses are associated with increased risk of cardiometabolic comorbidities. The objective of this study was to evaluate the prevalence of cardiometabolic comorbidity and its association with hospitalization outcomes and costs among inpatients with schizophrenia or bipolar disorder. METHODS This retrospective database analysis reviewed patients with an inpatient di...

Bipolar disorder affects many aspects of an individual's life and greatly interferes with a person's ability to find and maintain employment. The evidence indicates that a majority of patients with bipolar disorder are not employed and many others are employed only part time. Job-related difficulties are common, and patients with bipolar disorder tend to have higher rates of absenteeism from wo...

BACKGROUND Cognitive deficits have been documented in patients with bipolar disorder. Further, it has been suggested that the degree and type of cognitive impairment differ between bipolar I and bipolar II disorder, but data is conflicting and remains inconclusive. This study aimed to clarify the suggested differences in cognitive impairment between patients with bipolar I and II disorder in a ...

BACKGROUND Mood disorders are associated with various neurocognitive deficits. However, few studies have reported the impairment of motor dexterity in unipolar depression and bipolar disorder. In the present study, manual dexterity was compared between unipolar major depression, bipolar disorder, and healthy controls. METHODS Manual dexterity was assessed by the Purdue pegboard test in 98 pat...

We aimed to analyzed the association between polymorphisms of the FKBP5 (FK506 binding protein 5) gene and subtypes of bipolar disorder. In the study, we included 195 bipolar disorder patients with psychotic features, 129 bipolar patients with melancholic depression, and 156 bipolar patients with a history of suicidal attempts. We found weak association between the haplotypes of the FKBP5 gene ...

BACKGROUND Thyroid hormone plays a role in both serotonin and catecholamine functions in the brain, and has been linked to abnormal mood states in bipolar disorder. Unlike most studies which have included only patients with bipolar I, this study evaluated triiodothyronine (T3) as an augmentation agent for treatment-resistant depression in patients with bipolar II and bipolar disorder NOS. MET...

AIM The present study aimed to compare cognitive signs of bipolar disorder patients with that of adult attention-deficit/hyperactivity disorder (ADHD) patients. METHOD The study comprised 66 bipolar disorder patients, 63 ADHD patients, and 58 healthy controls.Structured Clinical Interview for DSM-IV Axis-I Disorders (SCID-I), Wender Utah Rating Scale, and Adult Attention-Deficit/Hyperactivity...

AIM Morphometric brain imaging studies have revealed regional brain abnormalities in patients with bipolar disorder, which may play a role in illness pathophysiology. It is not known whether such changes are of neurodevelopmental, neurodegenerative, or combined origin. We reviewed the anatomical brain imaging literature in bipolar disorder, in an attempt to determine whether there is evidence t...