نتایج جستجو برای: birc5

تعداد نتایج: 294  

Journal: :Annals of the Rheumatic Diseases 2021

Background: Interferon-gamma (IFNg) producing effector T cells play the leading role in triggering and perpetuation of inflammation rheumatoid arthritis. Inflammation leads to metabolic reprogramming high energy consumption supporting proliferation IFNg production. Being a part chromosomal passenger complex, oncoprotein survivin is essential for cell proliferation. It has also been identified a...

Journal: :Biochemical and biophysical research communications 2012
Chunyang Xing Haiyang Xie Lin Zhou Wuhua Zhou Wu Zhang Songming Ding Bajin Wei Xiaobo Yu Rong Su Shusen Zheng

Cyclin-dependent kinase inhibitor 3 (CDKN3) belongs to the protein phosphatases family and has a dual function in cell cycling. The function of this gene has been studied in several kinds of cancers, but its role in human hepatocellular carcinoma (HCC) remains to be elucidated. In this study, we found that CDKN3 was frequently overexpressed in both HCC cell lines and clinical samples, and this ...

Journal: :Cell 2012
Joseph Rosenbluh Deepak Nijhawan Andrew G. Cox Xingnan Li James T. Neal Eric J. Schafer Travis I. Zack Xiaoxing Wang Aviad Tsherniak Anna C. Schinzel Diane D. Shao Steven E. Schumacher Barbara A. Weir Francisca Vazquez Glenn S. Cowley David E. Root Jill P. Mesirov Rameen Beroukhim Calvin J. Kuo Wolfram Goessling William C. Hahn

Wnt/β-catenin signaling plays a key role in the pathogenesis of colon and other cancers; emerging evidence indicates that oncogenic β-catenin regulates several biological processes essential for cancer initiation and progression. To decipher the role of β-catenin in transformation, we classified β-catenin activity in 85 cancer cell lines in which we performed genome-scale loss-of-function scree...

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