Only a few agonists exhibit selectivity between the AMPA and the kainate subtypes of the glutamate receptor. The most commonly used kainate receptor preferring agonist, (S)-2-amino-3(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid [(S)-ATPA], is an (R,S)-2-amino-3-(5-methyl-3-hydroxy-4-isoxazolyl)propionic acid (AMPA) derivative in which the methyl group at the 5-position of the isoxazole ri...

This research includes the synthesis of new bis-Schiff bases linked to different imide cycles. There were some steps involved in novel Schiff with succinimide, phthalimide, tetrachlorophthalimide, and tetrabromophthalimide The first step preparation 4,4`-bis[(4-aminophenyl) methyl benzylidene]tolidine (1) via condensation reaction 3,3'-dimethyl-(1,1'-biphenyl)-4,4'-diamine 4-amino acetophenone....

In an investigation of the mechanisms of the neuroprotective effects of theanine (gamma-glutamylethylamide) in brain ischemia, inhibition by theanine of the binding of [3H](RS)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, and [3H](E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1-H-indole-2-carboxylic acid (MDL 105,519) to glutamate receptors was studied in terms ...

Elsden (1945) has shown that the volatile acids in the rumen fluid of sheep are chiefly acetic, propionic, and butyric. Barcroft, MoAnally, and Phillipson (1944) showed that the concentration of volatile acids in the blood draining the rumen was higher than that in the entering blood, indicating absorption from the rumen. Elsden postulated that propionic acid did not arise directly in cellulose...

This experiment investigated the effect of intraruminal infusion of propionic acid on ruminal VFA metabolism and the absorption of nutrients by the mesenteric- and portal-drained viscera of seven Friesian steers, average BW 127 kg, fed a dried grass-pellet diet. Each received by random allocation 0 (control), .5, or 1.0 mol of propionic acid/d for 7 d. Ruminal acetate and propionate irreversibl...

I . The plasma levels of individual amino acids were studied in dairy cows under different conditions of production and energy nutrition. 2. A preliminary experiment was conducted which established that there was no regular change in amino acid levels with time of sampling in animals offered food twice daily at milking. 3. For animals in the 8th month of pregnancy plasma concentrations of lysin...

In this work we report the preparation of two metallamacrocyclic tetranuclear manganese(II) complexes, [L1(4)Mn4](ClO4)4 and [L2(4)Mn4](ClO4)4 where L1 and L2 are the anions of the heptadentate ligands 2-((2-(bis(pyridin-2-ylmethyl)amino)ethyl)(methyl)amino)acetic acid and 2-(benzyl(2-(bis(pyridin-2-ylmethyl)amino)ethyl)amino)acetic acid), respectively. The complexes have been fully characteriz...

Hemoglobin prepared from red blood cells of adult Japanese Monkeys (Macaca fuscata fuscata) was removed heme so that globin was obtained. The • @ globin • @ was • @ separated • @into • @ ƒ¿ • @ and ƒÀ polypeptide • @ chains • @ by • @ countercurrent distribution with the system of sec-butanol containing trichroloacetic acid, propionic • @ acid, • @and • @water. • @ The,ƒÀ • @ polypeptide • @ ch...