In the original article, under the "Declaration of Interests" section, the authors stated "none declared" since they had no direct interest in the use of local anaesthetics to treat cancer (the focus of the article being the beneficial use of local anaesthetics in cancer surgery). However, they do have a pending patent on blockers that specifically target the persistent current component of vol...

Background: Laparotomy for major abdominal surgery, in particular emergency laparotomy, is associated with high rates of postoperative complications, mortality, and pain.1 Enhanced recovery guidelines highlight the importance opioid-sparing techniques perioperative period.2 Catheter insertion into posterior rectus sheath can be performed by anaesthetist under ultrasound guidance infusion local ...

the mean duration of ventilation was comparable in the two groups (11.0 h after standard cardiac anaesthesia vs 8.1 h in the fast-track patients). Nausea was reported in 11=106 (10.4%) and vomiting occurred in 16=106 patients (15.1%). Whilst our overall incidence of PONV was remarkably similar to Kogan's (25.5% vs 24%, respectively), a greater percentage of those with postoperative nausea actua...

Spahn DR. Patient blood management in orthopaedic surgery: a four-year follow-up of transfusion requirements and blood Effects of intravenous iron combined with low-dose recombinant human erythropoietin on transfusion requirements in iron-deficient patients undergoing bilateral total knee replacement arthroplasty. Effect of single recombinant human erythropoietin injection on transfusion requir...

Lipoprotein lipase (LPL), a key enzyme in normal lipoprotein metabolism, has a complex pattern of regulation and tissue-specific expression. Several potential binding sites for transcription factors, including the recognition sequences for CCAAT/enhancer-binding protein and octamer-binding proteins (Oct) have been described in the 5'-flanking region of the human LPL gene. To identify elements w...

These guidelines provide a strategy tomanage unanticipated difficultywith tracheal intubation. Theyare founded on published evidence. Where evidence is lacking, they have been directed by feedback from members of the Difficult Airway Society and based on expert opinion. These guidelines have been informed by advances in the understanding of crisis management; they emphasize the recognition and ...

Pharmacological perioperative brain neuroprotection: a qualitative review of randomized clinical trials. Br J Anaesth 2013; 110: i113–20 17. Brucken A, Cizen A, Fera C, et al. Argon reduces neurohistopathological damage and preserves functional recovery after cardiac arrest in rats. Br J Anaesth 2013; 110: i106–12 18. Lobo N, Yang B, Rizvi M, Ma D. Hypothermia and xenon: novel noble guardians i...

Editor—We recently came across an editorial in the British Journal of Anaesthesia entitled 'Is sedation by non-anaesthetists really safe?' written by Drs Webb and Hunter. 1 This topic is becoming more and more at the forefront in our speciality. After spending many years as an anaesthesiologist and taking care (hands on) of patients, including neonates and patients up to 106 yr old, using all t...

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Background: Inadvertent perioperative hypothermia (IPH) is a common consequence of anaesthesia, defined as core body temperature <36.0°C.1 Adverse effects include surgical site infection, coagulopathy, pain, altered drug metabolism, and adverse cardiac events.1 Preventing IPH vital part the enhanced recovery after surgery programme (ERAS).2 NICE clinical guideline (CG65) provides recommendation...