The aim of this work is to establish the most important epidemiologic features of malignant bladder tumors (based on the investigations so far), to get an insight into the risk factors and explain possible association with Balkan endemic nephropathy. Data from the most important studies were used, published in the country and abroad in scientific literature. Morbidity and mortality rates were e...

Complex organization of CNS and PNS pathways is necessary for the coordinated and reciprocal functions of the urinary bladder, urethra and urethral sphincters. Injury, inflammation, psychogenic stress or diseases that affect these nerve pathways and target organs can produce lower urinary tract (LUT) dysfunction. Numerous neuropeptide/receptor systems are expressed in the neural pathways of the...

This review provides a comprehensive view of translational research aimed at elucidating the pathophysiology of pediatric lower urinary tract dysfunction (LUTD). A web search was conducted according to combinations of keywords, and the significance of each article was defined by the author. The dramatic evolution of the mass analysis method of genomes, transcripts, and proteins has enabled a co...

AIM In this study we report our experience with microhematuria and its relation with bladder tumors in Iranian women. MATERIALS AND METHODS Overall 249 women were evaluated. Microscopic hematuria was defined as three or more red blood cells per high-power field on at least two different occasions. Patients with a history of gross hematuria or coagulation disorders, having organic diseases, ur...

Members of the tumor necrosis factor (TNF) superfamily have been revealed to be associated with painful bladder syndrome/interstitial cystitis (PBS/IC). TNF ligand-related molecule 1A (TL1A) and its receptor, death receptor 3 (DR3), belong to the TNF superfamily and have been implicated in chronic inflammatory diseases. Bladder biopsies from 8 female patients clinically diagnosed with PBS/IC ac...

In ̄ammation of the bladder is a common disease mainly affecting women. Patients may complain of suprapubic pain, urinary frequency and urgency with or without haematuria on repeated occasions. In many cases, urine analysis reveals white and red blood cells, while a positive bacteriological culture will con®rm an infectious cause of the cystitis. However, if the culture is negative, with or with...

Patients with diabetes have a higher incidence of bladder cancer; however, the association between thiazolidinedione use and bladder cancer risk has been controversial. We aimed to investigate whether pioglitazone or rosiglitazone use is associated with bladder cancer risk in patients with type 2 diabetes mellitus.This nationwide nested case-control study used data set obtained from the Korean ...